Colon Cancer, Muscle Strengthening
Conditions
Brief summary
Colon cancer is a real public health problem with more than 46,000 new cases diagnosed per year in France and about 650 cases in Burgundy. Muscle deconditioning (MD), which is characterized by a loss of muscle mass and function, is a frequent consequence in cancer patients and conditions the prognosis. Therefore, it is essential to understand its complex etiology in oncology in order to address the real need for therapeutic countermeasures in clinical practice. DM is a multifactorial process that is exacerbated by therapies. It induces neurogenic and muscular alterations that can profoundly affect patients' quality of life. Currently, analyses of this phenomenon in oncology have been limited essentially to a global evaluation of physical performance, neglecting the muscular and nervous nature of the adaptations responsible for it. Most studies analyzing the therapeutic effects of physical activity (PA) have shown numerous physiological and psychological benefits of aerobic exercise. However, this form of PA is still not very effective in preserving muscle mass. Only muscle strengthening can have an anabolic effect by accelerating the rate of protein synthesis.
Interventions
PROCEDUREMuscle biopsies
Optional In pre-training: Biopsy performed during the digestive surgery procedure Final evaluation (minimum 1 day and maximum 7 days after the last training session): biopsy performed in the digestive surgery department.
OTHERMuscle Strengthening
3 sessions per week for 18 weeks. Duration: 1 hour Training on different strength training machines for the main muscle groups of the lower and upper limbs. The training load will be gradually increased over the sessions.
BIOLOGICALBlood and urine samples
fasting blood sample taken at assessments 1, 2, 3 and 4 for patients and assessment 1 for controls
OTHERAerobic Training
3 sessions per week for 18 weeks. Duration: 1 hour Training on a classic pedal bicycle (called an ergocycle). The intensity and duration of the training will be gradually increased over the sessions and according to the patient's abilities.
OTHEREvaluation 1 pre-surgery
Carried out at least 15 days before surgery 1. st visit: * Nutritional assessment * Body composition * Psychometric tests of quality of life + IPAQ Test * VO2pic 2. nd visit: * Neuromuscular tests * Functional tests
OTHEREvaluation 2 post-surgery
1. st visit: * Body composition * Nutritional assessment * Psychometric tests of quality of life 2. nd visit: * neuromuscular tests * Functional tests * Familiarization with training equipment if patient participates in re-training
OTHERIntermediate Evaluation 3
performed 9 weeks after the beginning of training Identical tests to evaluation 1 + TM6
OTHERFinal post-training evaluation 4
Tests identical to evaluation 1 + TM6
Sponsors
Centre Hospitalier Universitaire Dijon
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Patient Inclusion Criteria : * Adult patients who are \< 80 years old * with a first diagnosis of colon cancer, regardless of TNM stage * to undergo a scheduled excision surgery (laparoscopic colectomy or laparoscopy) * with WHO stage \< 1 to the inclusion visit * having given their written consent * living close to the participating center (\<50 km) * ability to understand instructions Criteria for inclusion of healthy subjects : * Adult who is \< 80 years old * matched by gender, age and BMI to a patient * with WHO stage \< 1 at visit V1 * no medical contraindications to the program * having given written consent
Exclusion criteria
* Criteria for exclusion of patients and healthy subjects : * Protected Adult * Person not affiliated to national health insurance * Pregnant or breastfeeding woman * uncontrolled hypertension * Suffers from unstable diabetes of any type * Suffers from heart disease. Pre-surgical VO2 test will confirm authorization. * Affected by any condition likely to complicate the performance of physical activity (neurological, psychiatric, neuromuscular disorders, severe osteoporosis) * Patient who received neo-adjuvant chemotherapy Patient-specific
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Acceptability of the program in terms of the number of sessions attended | Up to Week 30 (evaluation 4) for patients | Tolerance in terms of level of effort and pain will be tested at each session and will condition the continuation or not of the sessions and therefore acceptability |
Countries
France
Contacts
Primary ContactAnaïs GOUTERON
Outcome results
None listed