Regenerative Endodontics for Non-vital Primary Molars

Clinical and Radiographic Evaluation of Regenerative Endodontics Using MTA and Biodentine for Non-vital Primary Molars Compared to Conventional Root Canal Treatment. (A Randomized Controlled Clinical Trial)

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05098483

Enrollment

Registered

2021-10-28

Start date

2023-09-05

Completion date

2024-10-26

Last updated

2025-07-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulp and Periapical Tissue Disease

Keywords

Regenerative endodontic treatment

Brief summary

Non-vital primary molars will be treated with regenerative endodontic idea using different capping materials aiming to replace the necrotic pulp tissue with biological one and to provide perfect seal over the scaffold

Detailed description

Non-vital primary molars that fulfill the eligibility criteria will be randomly assigned into one of the 3 study groups: Group 1: conventional root canal treatment Group 2: Regenerative endodontic treatment using MTA Group3: Regenerative endodontic treatment using Biodentine Each group will be followed up for 12 months

Interventions

PROCEDURERegeneration in primary molars by using MTA

Regenerative endodontic procedure in nonvital primary molars using MTA capping material

PROCEDURERegeneration in primary molars by using biodentine

Regenerative endodontic treatment in primary molars with biodentine as capping material

PROCEDUREConventional Root canal treatment in primary molars

Removal of pulp tissue from the canals of primary molars

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

4 Years to 7 Years

Healthy volunteers

Yes

Inclusion criteria

* Non-vital mandibular primary second molar. * Restorable tooth

Exclusion criteria

* Patients allergic to medicaments or antibiotics necessary to complete the procedure. * Special Health Care Needs * Excessive mobility * Presence of internal or external root resorption.

Design outcomes

Primary

Measure	Time frame	Description
Clinical measures	12 months	39 children with no pain or swelling (i.e) successful outcomes
Radiographic measures	12 months	39 children with no furcal radiolucency or presence of internal resorption. (i.e) successful outcome

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026