ARDS, Platelet Abnormality
Conditions
Brief summary
Detection and determination of platelets in bronchoalveolar lavage fluid and blood in ARDS and non-ARDS-patients. Correlation with phenotype and inflammation parameters in blood and outcome parameters.
Interventions
DIAGNOSTIC_TESTBronchoscopy, blood sampling; testing.
BAL and blood samples are measured by hematology analyzer, flow cytometry, western blot, RNAseq analysis and multiplex.
Sponsors
Study Chair and Principal Investigator: Univ.-Prof. Dr. Alexander Zarbock
Principal Investigator: Dr. Andreas Margraf
University Hospital Muenster
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Routine bronchoscopy * Patient in perioperative setting * Age \>=18 years * Consent
Exclusion criteria
* Active or recent (in past 7 days) bleeding in upper airways * Recent traumatic injury of the lung associated with (micro-)hemorrhage * Blood aspiration * Pregnancy * Age\<18 years * Acute kidney injury / Chronic kidney failure / Dialysis * Transplantation * HIV * Hematologic diseases * Immunosuppression * Anti-Platelet-Therapy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detectability and changes in platelets in BAL and blood | 5-7 days |
| Organ failure, survival. | 1 Year |
| Systemic platelet and leukocyte numbers | 5-7 days |
| Systemic platelet and leukocyte phenotypes. | 5-7 days |
| Systemic cytokine profiles. | 5-7 days |
Countries
Germany
Contacts
Primary ContactCarola Wempe, Dr
Backup ContactAndreas Margraf, Dr
Outcome results
None listed