The Effect of HFNC on Exercise Capacity Compared to VM in COPD Patients Recovering From Acute Evacerbation

The Effect of High Flow Nasal Cannula on Exercise Capacity Compared to Venturi Mask in COPD Patients Recovering From Acute Evacerbation

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05097560

Enrollment

Registered

2021-10-28

Start date

2021-08-11

Completion date

2022-08-31

Last updated

2021-10-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COPD

Keywords

HFNC, PR

Brief summary

Early PR is thought to be effective in COPD patients recovering from acute exacerbation, while the effect of HFNC during exercise training in these patients remains unclear. The study may provide evidence of early PR in COPD patients recovering from acute exacerbation.

Detailed description

We hypothesize that HFNC may increases exercise time in COPD patients recovering from acute exacerbation compare to VM. A randomized, cross-over clinical trial in which either HFNC or VM may be used as an adjunct in 10-MST in random order, respectively, will be performed to compare the endurance time. The physiological effect of HFNC and VM during exercise will also be measured to explore the mechanism.

Interventions

DEVICEhigh flow nasal cannula

HFNC provides humidified, heated, oxygen-enriched air at constant concentration with a flow up to 60L/min through a nasal cannula. It washouts the anatomical dead space and decreases the work of breathing.

DEVICEVenturi mask

VM is commonly used by COPD patients during exercise training.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

40 Years to 80 Years

Healthy volunteers

Inclusion criteria

* hospitalized AECOPD patients * be ambulatory by 48h after admission for AECOPD * requires oxygen by screening exercise test

Exclusion criteria

* active coronary ischemia * respiratory diseases other than COPD * unstable vital signs * unstable psychological status

Design outcomes

Primary

Measure	Time frame	Description
Endurance time	10 minute	Endurance time for 10 minute steping test

Secondary

Measure	Time frame	Description
Respiratory pattern	10 minute	Respiratory pattern is calculated by the flow and time
Work of breathing	10 minute	Work of breathing is calculated by the transdiaphragmatic pressure
Neural respiratory drive	10 minute	Neural respiratory drive is calculated by diaphragm electromyogram

Countries

China

Contacts

Primary ContactShiying Fang, MD

fangshiying2019@126.com+8602083062882

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026