UNC Childhood, Adolescent, and Young Adult Cancer Cohort

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05096923

Acronym

UNC-CAYACC

Enrollment

500

Registered

2021-10-27

Start date

2021-12-17

Completion date

2031-12-31

Last updated

2026-05-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer, Cancer Metastatic, Pediatric Cancer, Survivorship

Keywords

Adolescent and young adult, AYA

Brief summary

Purpose: This study aims to create a registry of childhood, adolescent, and young adult patients with cancer (\<40 years-old at cancer diagnosis), entitled the 'UNC Childhood, Adolescent, and Young Adult Cancer Cohort' (UNC-CAYACC). This resource will serve to support cancer outcomes research among pediatric and young adult cancer patients with a primary focus on enrolling patients treated as adolescents or young adults (AYAs, 15-39 years). Procedures: As appropriate for age, participants will complete physical and cognitive functional assessments; questionnaires to assess health-related quality of life and other patient-reported outcomes; will undergo body composition and anthropometric measurements; and will be asked to provide biospecimens for biobanking. Assessments will be collected (as possible) at diagnosis, during active treatment, following treatment completion, and annually in survivorship to assess outcomes throughout the treatment and survivorship trajectory. Sociodemographic and clinical information such as cancer treatment modalities and cumulative doses will be collected by medical record abstraction. Participants will be eligible to enroll at any time from diagnosis through survivorship. This registry will provide data to better understand the manifestations of accelerated aging and key contributing factors among children, adolescents, and young adults with cancer.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Years to 39 Years

Healthy volunteers

Inclusion criteria

* Patient ages 0-39 years at the time of cancer diagnosis (ages 1-39 years at enrollment) who are at any point in treatment and survivorship trajectory * English or Spanish speaking

Exclusion criteria

* Unwilling to sign informed consent * Speak a language other than English or Spanish.

Design outcomes

Primary

Measure	Time frame	Description
Registry development	Five years	Creation of a registry of pediatric and young adult patients with cancer treated within the University of North Carolina Health System
Functional assessments	Five years	Assess feasibility for completing repeated physical and cognitive functional assessments among young cancer survivors. These assessments include measures of physical and general frailty.

Secondary

Measure	Time frame	Description
Collection of sociodemographic, cancer, and treatment variables	Five years	Assess feasibility for collection of sociodemographic (including social determinants of health), cancer (e.g., site and stage), and treatment (e.g., modalities and cumulative doses) variables using patient questionnaires and medical record abstraction.
Collection of patient-reported outcome measures	Five years	Assess feasibility for the repeated collection of patient-reported measures of health-related quality of life, health behaviors, and functional status.

Countries

United States

Contacts

CONTACTAndrew Smitherman, MD

andrew_smitherman@med.unc.edu919-966-1178

CONTACTLauren Lux, MSW

lauren_lux@med.unc.edu984-974-8686

PRINCIPAL_INVESTIGATORAndrew Smitherman, MD

University of North Carolina, Chapel Hill

Outcome results