Autism Spectrum Disorder, Oxytocin
Conditions
Keywords
Autism, MEG, Social perception
Brief summary
The investigators explored the neural and behavioral effect of oxytocin on youth with Autism spectrum disorder using magnetoencephalography (MEG). The investigators hypothesize that oxytocin will modulate neural activity to resemble patterns observed in the age-matched control group. Thirty-two adolescents with autism and 26 typically developing adolescents participated in this randomized, double-blind MEG study. Individuals with autism arrived at the lab twice and received an acute dose of intranasal oxytocin or placebo in each session. During the scans, participants were asked to complete several tasks related to social perception - such as identification of social and non-social stimuli.
Detailed description
In the current study, the investigators aimed to explore oxytocin's influences on neural components that relate to social processing. Namely, we focused on M100, M170, and M250, which tend to show atypical patterns in individuals with autism. The investigators also examined the effects of oxytocin on time dynamics - the change in specific oscillation over time and its effects on neural connectivity patterns.
Interventions
DRUGOxytocin: Including placebo
Individual received age-dependent dosing of oxytocin and placebo. Participants aged 13-18 years received a dose of 24 IU (3 puffs to each nostril), and younger participants (aged 12 years) received 16 IU.
Sponsors
Prof. Ilanit gordon
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Caregiver, Investigator)
Intervention model description
Youth with autism participated in a randomized, double-blind placebo-controlled trial. Participants visited the lab for two sessions. In one of the sessions, they received oxytocin, and in the other, they received the placebo. Intranasal doses of 40 international units of oxytocin (IU)/mL were prepared by the Maayan-Haim pharmacy, Israel. We used age-dependent dosing such that participants aged 13-18 years received a dose of 24 IU (3 puffs to each nostril), and younger participants (aged 12 years) received 16 IU. Typically-developing youth underwent the same experimental procedure but did not receive oxytocin or placebo due to ethical constraints in Israel.
Eligibility
Sex/Gender
MALE
Age
12 Years to 18 Years
Healthy volunteers
Yes
Inclusion criteria
* Males, aged 12-18 years * Native Hebrew speakers * Normal or corrected-to-normal vision * Participants in the ASD group had to meet the criteria for ASD in the diagnostic and statistical manual of mental disorders (DSM-5)
Exclusion criteria
* Chronic medical problems * Cardiovascular risk factors * CNS disease * Other mental illnesses * Use of prohibited medications * Mental retardation * Impaired vision * Impaired hearing * History of significant head injury or neurological illness * Current substance dependence diagnosis * Metallic implants, braces or devices in the body
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The change in social-related neural components (time-locked neural activity) with and without oxytocin | During each session | The amplitude (tesla) of three social related neural components will be measured using MEG device |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The change in oscillatory activity - power magnitude of Delta, Theta, Alpha, Beta and Gamma neural bands with and without oxytocin | During each session | The overall power of neural oscillatory activity will be measured using MEG device |
| The change in behavioral measurments - reaction times and accurecy rates, with and without oxytocin | During each session | Reaction times will be measured in milliseconds and accurecy rates will be defined as the percentage of correct responses |
Outcome results
None listed