Burn Shock
Conditions
Brief summary
The adequacy of fluid resuscitation will be monitored in burn patients using microcirculation. Microcirculation camera will be placed on the base of the tongue and at different four quadrants. • Microcirculation parameters at baseline and after 8h , 16h and 24h of fluid resuscitation will be recorded. Fluid resuscitation with lactated ringer according to Parkland formula (4 ml/kg/%TBSA) 50% given during the first 8 hours, with the remainder given during the following 16 hours, will be initiated to maintain a urinary output of 0.5ml/kg/hr.Norepinephrine infusion will be started in case of circulatory failure at a rate of 0.02mic/kg/min to maintain MAP of 65-70mmHg.
Interventions
DEVICEMicrocirculation cytocam
Visualization of tongue microcirculation
Sponsors
Cairo University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age more than 18 years old * Burn \>20% TBSA * Patients with burn admitted within the 1st 6 hours
Exclusion criteria
* Age \< 18 years old. * Pregnant patients. * Patients with severe renal insufficiency. * Patients shocked due to other causes as sepsis, hypovolaemia or cardiogenic shock * Patients with airway edema that preclude the measurement of sublingual microcirculation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| • Lactate level | 24 hours | mmol/L |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| total vessel density | 24 hours | mm/mm2 |
Countries
Egypt
Contacts
Primary ContactShymaa Fathy, MD
Backup ContactShymaa Mahmoud, MMSc
Outcome results
None listed