Hip Fracture Surgery, Older People, Postoperative Delirium
Conditions
Keywords
Postoperative delirium, Older people, Cytokines, Self-reported Health Status
Brief summary
An investigation of the change in inflammation marker levels across hip fracture surgery and an exploration of any association with change in self reported health status and incidence of postoperative delirium
Interventions
PROCEDUREHip fracture Surgery (Primary)
Surgery for primary hip fracture requiring general or neuro-axial anaesthesia
Sponsors
University of Nottingham
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥ 65 years old * Admitted for primary hip fracture surgery
Exclusion criteria
* Preoperative cognitive impairment * History of neurosurgery, neurologic diseases or head trauma * Current systemic bacterial or viral infection * Complex or multiple injuries
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of postoperative delirium | 5 days | Assessment for presence or absence of delirium during the post operative period. |
| Cytokine dynamics | 2 days | Difference preoperative serum cytokine levels and postoperative serum cytokine levels in pg/mL. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Self reported health related quality of Life | 120 days | Assessed preoperatively and again at approximately 120 days after surgery using the EuroQol Five Dimension Five level (EQ-5D-5L) tool. The tool assesses on five aspects of health (Dimensions) and each dimension has five possible levels. The tool also has a visual analogue scale ranging from 0 (poorest) to 100 (best health) |
Countries
United Kingdom
Contacts
Primary ContactAbiodun Noah, FRCA
Backup ContactIain Moppett, DM
Outcome results
None listed