Arterial Stiffness, Heart Failure With Preserved Ejection Fraction, Lipid Disorder
Conditions
Brief summary
Heart failure with preserved ejection fraction (HFpEF) was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and arteriosclerosis. Studies have found that hypertension and obesity are respectively associated with increased arterial stiffness. However, there is still no research investigating the the relationship between lipids distribution and arterial stiffness in HFpEF patients.
Detailed description
Before the 21st century, Heart failure with preserved ejection fraction (HFpEF) was considered as a disease with simple diastolic dysfunction, but after the 21st century, HFpEF was considered as a heterogeneous disease with multi-organ and multi-system design, which is related to various complications, such as hypertension, obesity and arteriosclerosis. Other studies have found that hypertension and obesity are respectively associated with increased arterial stiffness. However, there is still no research investigating the the relationship between lipids distribution and arterial stiffness in HFpEF patients.
Interventions
None listed
Sponsors
Chongqing Medical University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
1. Adult aged \>=18years old; 2. Diagnosed with HFpEF. Diagnostic criteria including: 1. left ventricular ejection fraction ≥50%； 2. with the symptoms and/or signs of heart failure； 3. BNP≥35 pg/mL and/or NTproBNP≥125 pg/mL； 4. at least one additional criterion: relevant structural heart disease(LVH and/or LAE) or diastolic dysfunction
Exclusion criteria
1. LVEF less than 45% at any time; 2. Severe liver failure; 3/Other causes of shortness of breath, such as severe pulmonary disease or severe chronic obstructive pulmonary disease; 4.Primary pulmonary hypertension; 5.Severe valvular disease of the left heart; 6.Chronically bedridden or incapacitated; 7.Age \<18 years old.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Arterial stiffness | 1 day after admission | The baPWV(cm/s) of HFpEF patients |
| adipose tissue distribution | 1 day after admission | The visceral fat area(cm\^2) in HFpEF patients |
Countries
China
Contacts
Primary ContactDongying Zhang, doctor
Outcome results
None listed