B Cell Leukemia, Lymphoma
Conditions
Keywords
SNP
Brief summary
To search for a genetic marker of B-cell leukemias and lymphomas in children of Kazakh nationality, a single nucleotide polymorphism (SNP) analysis of DNA obtained from the peripheral blood of patients with B-cell leukemias and lymphomas in children of Kazakh nationality and normal control will be performed.
Interventions
GENETICSNP analysis of the DNA
SNP analysis of the DNA obtained from peripheral blood sample
Sponsors
Asfendiyarov Kazakh National Medical University
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
0 Years to 18 Years
Inclusion criteria
* ethnicity - Kazakhs in at least three generations * active disease or a history of B-line ALL or B-NHL, established on the basis of morphological, cytochemical, immunophenotypic or immunohistochemical research methods with confirmation of the fact of the disease in medical documentation * Signed voluntary informed consent of the legal representative to participate in the project
Exclusion criteria
* Children suffering from other types of malignant neoplasms * Children with B-linear leukemia and lymphomas with concomitant specified genetic and chromosomal diseases * Children of non-Kazakh nationality * Absence of signed informed consent or informed refusal of the legal representative to participate in the study before starting therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Associated with B-cell lymphoma and B-cell acute lymphoblastic leukemia | 1 year | Genotype frequency of SNP in the study genes of participants and control participants. |
Countries
Kazakhstan
Outcome results
None listed