Idiopathic Osteoarthritis
Conditions
Keywords
SNP
Brief summary
The purpose of this study is to identify genetic determinants of susceptibility to idiopathic osteoarthritis of the knee . It will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms of idiopathic osteoarthritis of the knee
Interventions
GENETICSNP analysis of the DNA
SNP analysis of the DNA obtained from peripheral blood sample
Sponsors
Asfendiyarov Kazakh National Medical University
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 68 Years
Inclusion criteria
1. Patients with bilateral idiopathic gonarthrosis aged 18 to 65 years; 2. Representatives of the Kazakh ethnic group up to the 3rd generation; 3. Hereditary history of arthrosis; 4. Persons who are able and willing to provide written informed consent;
Exclusion criteria
1. Patients with bilateral idiopathic gonarthrosis under 18 years of age and over 65 years of age; 2. Representatives of other ethnic groups; 3. Representatives of the Kazakh ethnic group less than 3 generations; 4. No family history of bilateral idiopathic gonarthrosis; 5. Patients with an acute period of the inflammatory process (laboratory and clinical signs); 6. Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent; 7. Pregnant or lactating women; 8. Tuberculosis of any localization in the active phase and in history; 9. Severe and decompensated diseases of the liver and kidneys, cardiovascular system; 10. Severe and decompensated course of endocrine diseases; 11. Autoimmune diseases; 12. Systemic diseases; 13. Oncological diseases;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| enotyping for the SNP associated with liver cirrhosis | 1 year | Genotype frequency of SNP in the study genes of participants and control participants. |
Countries
Kazakhstan
Outcome results
None listed