Idiopathic Scoliosis
Conditions
Keywords
SNP
Brief summary
The purpose of this study is to identify genetic determinants of susceptibility to idiopathic scoliosis . It will assist in predicting individual risks of disease progression and would help to clarify pathophysiologic mechanisms of idiopathic scoliosis
Interventions
GENETICSNP analysis of the DNA
SNP analysis of the DNA obtained from peripheral blood sample
Sponsors
Asfendiyarov Kazakh National Medical University
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
4 Years to 40 Years
Inclusion criteria
1. Persons with a doctor-confirmed diagnosis of idiopathic scoliosis; 2. Persons of Kazakh nationality, whose paternal and maternal grandparents are Kazakhs; 3. Hereditary history of scoliosis; 4. Persons who are able and willing to provide written informed consent;
Exclusion criteria
1. Patients diagnosed with idiopathic scoliosis under 4 and over 40 years of age; 2. Representatives of the Kazakh ethnic group less than 3 generations; 3. No family history of bilateral idiopathic scoliosis; 4. Patients with an acute period of the inflammatory process (laboratory and clinical signs); 5. Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent; 6. Pregnant or lactating women; 7. Tuberculosis of any localization in the active phase and in history; 8. Severe and decompensated diseases of the liver and kidneys, cardiovascular system; 9. Severe and decompensated course of endocrine diseases; 10. Autoimmune diseases; 11. Systemic diseases; 12. Oncological diseases;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Genotyping for the SNP associated with liver cirrhosis | 1 year | Genotype frequency of SNP in the study genes of participants and control participants. |
Countries
Kazakhstan
Outcome results
None listed