Pneumonia, Bacterial, Subarachnoid Hemorrhage
Conditions
Keywords
Subarachnoid hemorrhage, pneumonia, delayed cerebral ischemia, vasospasm, delayed cerebral infarction
Brief summary
Prognosis of subarachnoid hemorrhage (SAH) is scarce, indeed almost half patients die or become severely disable after SAH. Outcome is related to the severity of the initial bleeding and delayed cerebral infarction (DCI). Infection and more precisely pneumonia have been associated with poor outcome in SAH. However, the interaction between the two pathologic events remains unclear. Therefore, we hypothesized that DCI may be associated to pneumonia in SAH patients. Thus the aim of the study is to analyze the association between delayed cerebral infarction and pneumonia in patients with SAH. Retrospective, observational, monocentric cohort study, including patient admitted in Neurosurgical Intensive Care Unit or Surgical Intensive Care Unit in the University Hospital of Brest (France) for non-traumatic SAH. Primary outcome is diagnosis of DCI on CT scan or MRI 3 months after SAH. Multivariate analysis is used to identify factors independently associated with DCI. We plan to include between 200 and 250 patients in the analysis.
Interventions
None listed
Sponsors
University Hospital, Brest
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* admitted in ICU in Brest University Hospital * for non traumatic subarachnoid hemorrhage * between july 2015 and december 2018
Exclusion criteria
* continuation of care out of Brest University Hospital after initial ICU stay * refusal to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| delayed cerebral infarction | 3 months from subarachnoid hemorrhage | infarction on CT or MRI not related to initial bleeding |
Countries
France
Outcome results
None listed