Analgesia After Video-Assisted Thoracic Surgery

Analgesic Efficacy of Ultrasound-Guided Deep Serratus Anterior Plane Block, Local Wound Infiltration, and Thoracic Paravertebral Block After Uniportal Video-Assisted Thoracic Surgery: A Randomized Trial

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05094323

Enrollment

102

Registered

2021-10-26

Start date

2022-02-18

Completion date

2025-10-15

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post Operative Pain

Brief summary

Although less invasive, postoperative analgesia remains challenging in patients undergoing uniportal video-assisted thoracic surgery (VATS).

Detailed description

Although less invasive, postoperative analgesia remains challenging in patients undergoing uniportal video-assisted thoracic surgery (VATS). Adequate postoperative pain relief is imperative to hasten functional recovery, accelerate discharge from the hospital, and reduce chronic postsurgical pain.

Interventions

DRUGUltrasound-guided deep serratus anterior plane block with isobaric bupivacaine

Patients will receive ultrasound-guided deep serratus anterior plane block with isobaric bupivacaine.

DRUGLocal wound infiltration with isobaric bupivacaine

Patients will receive local wound infiltration with isobaric bupivacaine.

DRUGUltrasound-guided thoracic paravertebral block with isobaric bupivacaine

Patients will receive ultrasound-guided thoracic paravertebral block with isobaric bupivacaine.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Patients scheduled for uniportal VATS under general anesthesia, ASA status I-III, aged from 18 to 70 years old of both sex.

Exclusion criteria

* Contraindications to regional block * Pregnancy * Body mass index (BMI) \> 30 Kg/m2 * Psychiatric diseases * Severe renal, liver, or cardiac dysfunction

Design outcomes

Primary

Measure	Time frame	Description
Time to first analgesic requirement	24 hours after surgery	Assessed in minutes

Secondary

Measure	Time frame	Description
Postoperative pain intensity	24 hours after surgery	Assessed by the numerical rating pain scale, an 11-point scale graded from 0 to 10 (0 = no pain, 10 = the worst imaginable pain)

Countries

Egypt

Contacts

PRINCIPAL_INVESTIGATORSeham M Moeen, MD

Assiut University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026