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Effect of Phosphate Exposure on Workers Health

Effect of Phosphate Exposure on Workers Respiratory and Oral Health in Phosphate Mine at Safaga

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT05094076
Enrollment
100
Registered
2021-10-26
Start date
2022-01-01
Completion date
2023-12-30
Last updated
2021-10-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Work-related Illness

Brief summary

To minimize negative health effects on health of workers in phosphate mining, it is important to assess, and diagnose health related effect of phosphate exposure & health hazards related to miners. Early reporting, diagnosis, and intervention can limit the severity of health hazards, improve the health services. To our knowledge no local previous studies were done in this area.

Detailed description

Mining continues to be a dangerous activity, whether large-scale industrial mining or small-scale artisanal mining. Not only are there accidents, but exposure to dust and toxins, along with stress from the working environment or managerial pressures, give rise to a range of diseases that affect miners. Beneficiation is the process of removing the unnecessary minerals, which is used to increase the grade of mining product (concentrate). Phosphate ores can be beneficiated using one or a combination of different methods. The most common ones are: flotation, crushing, desliming, separation, grinding and washing thus keeping workers in Phosphate mines employ exposed to respirable dust pollution and to high silica dust levels presented in silicosis in many job areas, Silicosis is the most common occupational lung disease in Egypt where its prevalence rate ranges from 18.5 % to 45.8% among workers exposed to free crystalline silica dust. Despite its high prevalence, there is a lack of enforcement of exposure limits, availability and use of personal protective equipment, and occupational health education programs . In Egyptian phosphate miners' study (2011), The study involved of three groups: 50 silica-exposed workers with radiological evidence of silicosis, 50 silica-exposed workers without evidence of silicosis, and 50 healthy unexposed subjects. , There were significant differences between pulmonary function parameters, values of C-reactive protein, rheumatoid factor, complement component C3, IgA, IgG, and IgM in exposed groups with and without silicosis, and healthy unexposed control subjects (p\<.001). Exposure to acid fumes in the phosphate mining was significantly associated with dental erosion and deteriorated oral health status, As working in phosphate mines had 8 and 28 times the risk for developing respectively oral lesions and teeth abrasions. This supported by Tunisian 2017 on 37 workers& 37 controls, found that frequencies of fluorosis, teeth abrasion, and oral lesions were significantly higher among the exposed group.

Interventions

RADIATIONchest x ray

The chest radiographs obtained will be classified according to the International Labor Organization (ILO) System for Classification of Radiographs for Pneumoconiosis \[ILO, 1980\]. Film quality, profusion, and shape and size of opacities will be evaluated by this method. Radiographic evidence of silicosis was defined as a profusion score of 1/0 or greater

Sponsors

Assiut University
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
MALE
Age
25 Years to 60 Years
Healthy volunteers
Yes

Inclusion criteria

* Active working miners working in phosphate mines with minimum exposure 5 year. * Had free pre-employment records.

Exclusion criteria

* Workers don't record phosphate exposure as in administration department. * Workers with less than 5-year exposure * Workers known to had autoimmune disorder before joining job.

Design outcomes

Primary

MeasureTime frameDescription
pneumoconiosis or notthrough study completion, an average of 1 yearThe chest radiographs obtained will be classified according to the International Labor Organization (ILO) System for Classification of Radiographs for Pneumoconiosis \[ILO, 1980\]. Film quality, profusion, and shape and size of opacities will be evaluated by this method. Radiographic evidence of silicosis was defined as a profusion score of 1/0 or greater

Secondary

MeasureTime frameDescription
dental cariesthrough study completion, an average of 1 yearThe DMFT index is one of the simplest and most used indices in epidemiologic surveys of dental caries. It quantifies dental health status based on the number of carious, missing and filled teeth

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026