Appendicitis Acute
Conditions
Brief summary
Acute appendicitis is a common and potentially serious medical condition which can be difficult to diagnose, especially in pediatric patients. To help recognize patients with acute appendicitis, number of laboratory and radiological test are used. Previous research has shown that Circulating Human Leucine-rich α-2-glycoprotein (LGR1) in the blood can be elevated in pediatric patients with acute appendicitis. The aim of this research is to analyse whether LGR1 levels in saliva can be used as a less invasive diagnostic method in pediatric patients with suspected acute appendicitis.
Interventions
DIAGNOSTIC_TESTBlood specimen collection
Blood specimen collection for analysis of CRP (C-reactive protein), WBC (White blood cells) and LRG1 (Circulating Human Leucine-rich α-2-glycoprotein) levels
DIAGNOSTIC_TESTSaliva specimen collection
Saliva specimen collection for analysis of LRG1 (Circulating Human Leucine-rich α-2-glycoprotein) levels
Sponsors
KBC Split
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
5 Years to 17 Years
Healthy volunteers
No
Inclusion criteria
* children with age from 5 do 17 with acute abdominal pain * children with clinical signs of appendicitis
Exclusion criteria
* previous diagnosis of chronic and/or malignant disease * children which had previous abdominal surgery * pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Level of LGR1 protein in blood | 72 hours | Levels of LGR1 protein in blood and saliva as measured by ELISA test |
| Level of LGR1 protein saliva | 72 hours | Levels of LGR1 protein in saliva as measured by ELISA test |
Countries
Croatia
Contacts
Primary ContactGoran Tintor, MD
Outcome results
None listed