Sleep Deprivation
Conditions
Brief summary
This research study will use magnetic resonance imaging (MRI) and olfactory stimuli to better understand the connection between sleep deprivation, brain activity, and olfaction in humans.
Interventions
BEHAVIORALSleep deprivation
Fully slept: Sleep habitual amount (i.e., go to sleep at habitual bedtime and wake up at habitual wake time) Sleep deprived: Reduce sleep by 50% (i.e., go to sleep at habitual bedtime and wake up early)
Sponsors
Northwestern University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* At least 18 years old * Fluent English speakers
Exclusion criteria
* History of neurological conditions (e.g., epilepsy, dementia, multiple sclerosis, brain tumors, etc.) * History of psychiatric conditions (e.g., general anxiety disorder, depression, schizophrenia, obsessive-compulsive disorder, post-traumatic stress disorder, attention deficit hyperactivity disorder, alcoholism, etc.) * Significant medical illnesses (e.g., cancer, meningitis, chronic obstructive pulmonary disease, cardiovascular disease, etc.) * Cerebrovascular risk factors (e.g., hypertension, diabetes, elevated cholesterol, etc.) * Use of psychoactive medications (e.g., barbiturates, benzodiazepines, chloral hydrate, haloperidol, lithium, carbamazepine, phenytoin, citalopram, escitalopram, fluoxetine, diazepam, etc.) * Smell or taste dysfunction * History of severe allergies requiring hospitalization for treatment * History of severe asthma requiring hospitalization for treatment * Habitual smoking * History of eating disorders (e.g., anorexia nervosa, bulimia nervosa, binge-eating disorder, etc.) * Dieting or fasting * History of sleep disorders (e.g., obstructive sleep apnea, narcolepsy, insomnia, etc.) Magnetic implants (e.g., shunts or stents, aneurysm clips, surgical clips, cochlear implants, metal bone/joint pins, plates and screws, eyelid spring or wires, etc.) * Electronic implants (e.g., implanted cardiac defibrillator, cardiac pacemaker, deep brain/spinal cord or nerve stimulator, internal electrodes/wires, medication infusion devices, etc.) * History of metal working without proper eye protection, or injury with metal shrapnel or metal slivers * Left-handedness * Claustrophobia
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Behavior an olfactory perceptual decision-making task | Up to 24 hours after the intervention | Food-like perceptual responses to binary food-nonfood odor mixtures |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Resting-state functional magnetic resonance imaging | Up to 24 hours after the intervention | Resting-state activity determined by functional magnetic resonance imaging |
Countries
United States
Outcome results
None listed