Healthy
Conditions
Brief summary
The goal of this study is to analyze certain biomarkers to look at the relationship between HPV in the saliva, stage at presentation, and a potential self-test compared to saliva of non-cancerous participants.
Interventions
OTHERno intervention
saliva collection
Sponsors
Mayo Clinic
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* Oropharynx or Oral Cavity Squamous Cell Carcinoma Patients: collected under the OPX Biomarker Protocol (IRB: 19-006036). Normal Controls: * Age ≥ 18 years; * Able to provide informed written consent documenting permission to give saliva sample for research testing.; * Ability to complete questionnaire(s) by themselves or with assistance.
Exclusion criteria
* Oropharynx or Oral Cavity Squamous Cell Carcinoma Patients: collected under the OPX Biomarker Protocol (IRB: 19-006036). Normal Controls: * Any personal history of head or neck cancer including head or neck skin cancer. * Other active malignancy ≤ 5 years prior to registration. * EXCEPTIONS: Non-melanotic skin cancer, non-metastatic prostate cancer. * NOTE: If there is a history of prior malignancy, they must not be receiving other specific treatment for their cancer. * Dry mouth (xerostomia) caused by any chronic (\>30 days) condition (known or unknown) or medication. * Recent (within 30 days) or active upper aerodigestive tract or anogenital infections.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oncologic strains in HPV DNA salivary samples | 2 years | Number of patients to have oncologic strains of HPV DNA in salivary samples |
Countries
United States
Outcome results
None listed