Physiological Response to Prone Position in COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS)

Physiological Response to Prone Position in Intubated Adults With COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS): a Retrospective Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05092737

Enrollment

Registered

2021-10-25

Start date

2021-08-01

Completion date

2022-04-30

Last updated

2022-06-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ARDS, Sars-CoV-2 Infection

Brief summary

Retrospective study in COVID-19 ARDS patients hospitalised in the ICU. Investigators aim to explore the effects of prone positioning on oxygenation, dead space ventilation and mortality.

Interventions

PROCEDUREProne positioning

Prone position during invasive mechanical ventilation

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* COVID-19 associated moderate to severe ARDS * Invasive mechanical ventilation * Prone positioning * admitted to ICU

Exclusion criteria

* already sustained prone positioning in referring hospital * pronation during ECMO only * denied consent for data analysis

Design outcomes

Primary

Measure	Time frame	Description
PaO2/FiO2	Within 2 hours before pronation and 2 hours before supination	Arterial partial pressure of oxygen / Fraction of inspired oxygen

Secondary

Measure	Time frame
Alveolo-arterial oxygen gradient change	Within 2 hours before pronation and 2 hours before supination
Ventilatory Ratio	Within 2 hours before pronation and 2 hours before supination
Mortality or Extracorporeal membrane oxygenation (ECMO) support	Once between ICU admission and extubation

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026