Atherosclerosis
Conditions
Keywords
resistance training
Brief summary
To study whether the resistance training with blood flow obstruction in patients in early atherosclerosis period can produce a beneficial effect on preventing atherosclerosis.
Interventions
BEHAVIORALexercise
Upper limb resistance training with blood flow obstruction
Sponsors
Nanjing First Hospital, Nanjing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
1. LDL \> 3.11mmol/l and less than 5.63mmol/l; 2. No serious heart, blood vessel and other related diseases; 3. There were no skeletal and muscular diseases affecting sports training; 4. No regular exercise in the past half year (no more than 2 times a week, no more than 30 minutes each time); 5. Smoking less than 1 pack / year, no history of drinking.
Exclusion criteria
1. Haven't other serious heart and vascular diseases other than hyperlipidemia and / or bones and muscles that affect sports training Diseases; 2. Pregnant women and people with disabilities; 3. Other circumstances determined by the researcher not suitable for the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Endothelium dependent vasodilation | 8 weeks | Percentage of the change |
| Blood lipid analysis results | 8 weeks | Content of total cholesterol, triglycerides, high density lipoprotein and low density lipoprotein |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The inflammatory state | 8 weeks | Content of NO, eNOS, iNOS, IFN-γ, IL-6, IL-10 in blood |
| Endothelial repair function | 8 weeks | eNOSmRNA, iNOSmRNA, EPCs in blood |
Countries
China
Contacts
Primary ContactAicui Lin, PhD
Backup ContactJunXia Zhang, PhD
Outcome results
None listed