The Effect of Injection Rate of Local Anesthetic in Caesarean Section

Does the Injection Rate of Local Anesthetic Affect the Onset of Sensory Block and Incidence of Hypotension in Caesarean Section

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05091294

Enrollment

Registered

2021-10-25

Start date

2020-02-11

Completion date

2021-07-30

Last updated

2022-02-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, Obstetrical, Anesthesia, Spinal

Brief summary

This randomized double-blind study aimed to compare the effects of two different subaracnoid lokal anesthetic injection rate in cesarean section. Totally 67 patients were included. The groups were compared in terms of maximum sensory and motor block level, time to reach T6 level, hemodynamic changes and nausea- vomiting saved.

Detailed description

A total of 67 patients 18-40 years undergoing cesarean, who were graded as American Society of Anesthesiologists physical status were randomly allocated into two groups, 120-sn injection time (n=34, Group F), 15-sn injection time (n=33, Group S). When the level of the sensory block achieve the T6 level the surgery was let to begin. The groups were compared in terms of hemodynamic values, use of efedrin, the time to achieve sensory block to the T6 level, maximum sensory block level and motor block level.

Interventions

OTHERLocal anesthetic injection rate in spinal anesthesia

Administering intrathecal local anesthetics for all patients according to height and weight.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Anesthesiologists risk score (ASA) I-II risk status * Singleton pregnancy aged * Between 18-40 years

Exclusion criteria

* Pregnant women with contraindications for spinal anesthesia; * Placental anomaly; * Hypertension * Cardiac disease * Vascular disease * Hepatic disease * Renal disease * Hemodynamic instability * Spinal deformity; * Severe mental retardation * Weight \< 50 kg or \>110 kg; height \< 140 cm or \> 180 cm * Metabolic and Acid-base balance disorders * Emergency patients

Design outcomes

Primary

Measure	Time frame	Description
sensory block	2 minutes interval	The time to reach the sufficient sensory block and maximum level of sensory block was significantly shorter in Group S
Hypotension	2 minutes interval	The time to onset of hypotension was significantly shorter in Group F

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026