Desmoid
Conditions
Keywords
desmoid tumor; cryotherapy
Brief summary
Desmoid tumor is a benign neoplasm with an unpredictable course and a high rate of local recurrence if treated surgically. Therefore, over time the surgical approach has become conservative, preferring simple observation or medical therapy in case of disease progression through the use of hormonal therapy and low-dose chemotherapy. Since this neoplasm remains benign, our study aims to avoid chemotherapy in patients usually young through the use of a minimally invasive treatment such as cryotherapy.
Interventions
PROCEDURECryotherapy
The procedure involves general or peripheral anesthesia and percutaneous treatment under CT control with probes capable of forming ice spheres of up to 3 cm that will be used in sufficient number to treat the neoplasm completely.
Sponsors
Istituto Ortopedico Rizzoli
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* histologic diagnosis of desmoid tumors * age \> 18 years * abdominal and extra-abdominal desmoid tumors
Exclusion criteria
* contraindication to the procedure by the interventional radiologist in terms of tumor proximity to neurologic/vascular structures * retroperitoneal desmoid tumors * age \< 18 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| response to treatment | At baseline (time 0) | assessment of tumor response to treatment will be performed using the solid tumor response criteria |
Countries
Italy
Contacts
Primary ContactCostantino Errani, MD
Outcome results
None listed