The Role of Genetic Factors in the Development of Breast Cancer in the Kazakh Population

Preventive and Personalized Medicine (2021-2023)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05090605

Enrollment

700

Registered

2021-10-25

Start date

2022-03-30

Completion date

2023-01-20

Last updated

2023-03-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast Cancer

Keywords

GWAS

Brief summary

This is a GWAS study that aims to identify possible candidate genes associate to breast cancer by exploring single nucleotide polymorphism (SNP) in a group of breast cancer, in the Kazakh population. The investigators hypothesize that the careful phenotyping of the subject sand matching with increase the power to find SNP significantly associate with breast cancer

Detailed description

A genome-wide association study (GWAS) is an approach used in genetics research to associate specific genetic variations with particular diseases. The method involves scanning the genomes from many different people and looking for genetic markers that can be used to predict the presence of a disease. Once such genetic markers are identified, they can be used to understand how genes contribute to the disease and develop better prevention and treatment strategies.

Interventions

GENETICDNA analysis

GWAS

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 60 Years

Inclusion criteria

* Persons with a histologically confirmed diagnosis of breast cancer. * The age of patients is from 18 to 60 years; * Persons of Kazakh nationality, whose paternal and maternal grandparents are Kazakhs. * Persons who are able and willing to provide written informed consent; * Persons capable and willing to comply with the research protocol;

Exclusion criteria

* Persons under 18 and over 60 years old; * Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent; * Pregnant or lactating women; * Tuberculosis of any localization in the active phase and in history; * Severe and decompensated diseases of the liver and kidneys, cardiovascular system; * Severe and decompensated course of endocrine diseases; * Lack of histological verification of breast tumor

Design outcomes

Primary

Measure	Time frame	Description
number of SNPs associated with breast cancer	1 year	Using GWAS to identify candidate genes associate with breast cancer

Countries

Kazakhstan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026