MTBI - Mild Traumatic Brain Injury
Conditions
Keywords
Mild Traumatic Brain Injury, MRI, gut microbiota
Brief summary
Traumatic brain injury (TBI) is the leading cause of disability in children and young adults. Children with moderate to severe TBI are typically at risk of poor functional outcome in terms of neurocognitive impairment and behavior problems. Neurocognitive impairments include deficits in attention and working memory, learning and memory, and executive functioning, whereas behavior problems include anxiety, depression and aggression. Neuroimaging techniques based on multi-modal magnetic resonance image (MRI) can detect the structural and functional brain abnormalities objectively and sensitively. Recent evidence indicates that even after mild TBI, children with risk factors for intracranial pathology are at risk of poor neurocognitive and behavioral outcome.Meanwhile, recently, the concept of gut-brain axis has been proposed and hint gut microbiota could shape the brain. Some studies have emphasized that human gut microbiota plays an important role in the pathogenesis and development of TBI. However, how the gut affects the brain in patients with TBI is unclear. Thus, combining analysis of neuroimaging and gut-brain axis will provide more information for finding the risk factors and imaging diagnostic markers of brain impairment in TBI. It will also helpful for explaining the underlying mechanisms of brain impairment in TBI, providing an objective basis for clinical diagnosis and prediction of the prognosis.
Interventions
DEVICEmagnetic resonance image
Imaging data were collected in a strong magnetic field
OTHERgut microbiota
gut microbiota
Sponsors
Xi'an Jiaotong University
The Second Affiliated Hospital and Yuying Childern's Hospital of Wenzhou Medical University
First Affiliated Hospital Xi'an Jiaotong University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
6 Years to 14 Years
Healthy volunteers
Yes
Inclusion criteria
* age 6-14 years at time of recruitment. * hospital admission with a clinical diagnosis of TBI for inclusion in the TBI group * GCS = 15-13. * loss of consciousness duration≤30 min. * post-traumatic amnesia duration ≤1 h.
Exclusion criteria
* previous TBI. * visual or auditory disorder interfering with neurocognitive testing. * current neurological condition affecting the central nervous system with known effects on neurocognitive functioning, other than TBI.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change from baseline brain structure measures at 6 months and 12months | baseline (early injury), post-traumatic for 6 months and 12 months | The changes of brain volume (mm3) are evaluated by structural MRI |
| Change from baseline brain function measures at 6 months and 12months | baseline (early injury), post-traumatic for 6 months and 12 months | The changes of brain functional connectivity intensity are evaluated by functional MRI |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes from baseline cognitive condition at 6 months and 12months | baseline (early injury), post-traumatic for 6 months and 12 months | The cognitive condition is assessed by Wechsler Intelligence Scale for Children-IV-Chinese Version (WISC-IV), higher scores represent better cognitive. |
| Changes from baseline behavior condition at 6 months and 12months | baseline (early injury), post-traumatic for 6 months and 12 months | the neuro-behavior condition is assessed by child behavior checklist（CBCL），higher scores represent better behavior symptoms. |
| Changes from baseline gut microbiota at 6 months and 12months | baseline (early injury), post-traumatic for 6 months and 12 months | Fecal samples were collected within 2 days before or after MR examination |
Countries
China
Contacts
Primary ContactMing Zhang, phD
Backup ContactLiJun Bai, phD
Outcome results
None listed