Delirium
Conditions
Keywords
Delirium, Postoperative, CAM-ICU Score
Brief summary
The study aims to observe the presence of postoperative delirium in patients undergoing elective cardiac surgery, without changing the pharmacological prescriptions of the enrolled patients and the procedures carried out by normal clinical practice.
Interventions
OTHERevaluation of delirium with CAM-ICU Score
the CAM-ICU score is an evaluation tool to verify the presence or absence of delirium in a subject
Sponsors
Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Inhibitors of serotoninergic reuptake on Inclusion Criteria: * patients over 18 years old * patients undergoing elective cardiac surgery * patients diagnosed with depressive syndrome requiring treatment with Inhibitors of serotoninergic reuptake excluding neurodegenerative diseases * patients on antidepressant therapy for more than 3 months at the time of enrollment
Exclusion criteria
* absence of written informed consent to the study * patients undergoing non-elective and emergency cardiac surgery * patients undergoing off pump surgery * patients with depression not on therapy * patients with existing malignancies * patients with acute infections in progress * patients with previous stroke, cerebral haemorrhage with relics * patients with acquired and congenital metabolic pathologies with CNS alterations * Patients with acute and / or chronic renal failure according to RIFLE score (exclude only F-L-E) * Patients with acute and / or chronic hepatic insufficiency according to Child - Pugh score \<6 (but without encephalopathy); * Patients with neurodegenerative diseases (dementias of all types both organic and vascular, parkinson's and ongoing delirium); * Patients with previous or current drug and / or alcohol abuse * pregnant or postpartum period patients (6 months after delivery) Inhibitors of serotoninergic reuptake off Inclusion Criteria: * patients over 18 years old * patients undergoing elective cardiac surgery * patients without a diagnosis of depressive and psychiatric illness requiring treatment with psychoactive drugs to the exclusion of neurodegenerative diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Presence/absence of postoperative delirium | 4 june 2020 to 4 june 2021 | presence / absence of postoperative delirium, assessed with CAM-ICU, from awakening and for the following 48 hours |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| correlation with Hospital-Length of Stay | 4 june 2020 to 4 june 2021 | correlation with Hospital-Length of Stay |
| Bleeding | 4 june 2020 to 4 june 2021 | measure of bleeding in ml / day |
| re-operated patient | 4 june 2020 to 4 june 2021 | Number of re-operated patient |
| Correlation with ICU-Length of Stay | 4 june 2020 to 4 june 2021 | Correlation with ICU-Length of Stay |
| mortality | 4 june 2020 to 4 june 2021 | mortality at 28 days |
| infections | 4 june 2020 to 4 june 2021 | number and type of infections that occurred following the operation |
| mechanical ventilation in intensive care | 4 june 2020 to 4 june 2021 | number of patients who required mechanical ventilation in the ICU |
Countries
Italy
Outcome results
None listed