The Role of Genetic Factors in the Development of Bronchial Asthma in the Kazakh Population

Preventive and Personalized Medicine (2021-2023)

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05088512

Enrollment

300

Registered

2021-10-22

Start date

2021-10-23

Completion date

2023-01-20

Last updated

2023-03-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bronchial Asthma, Genome Wide Association Studies

Keywords

Bronchial Asthma, Genome Wide Association Studies

Brief summary

To research for a genetic marker of bronchial asthma, a single nucleotide polymorphism (SNP) analysis of DNA obtained from the peripheral blood of patients with bronchial asthma and normal control will be performed.

Detailed description

Unrelated Kazaks subjects who have bronchial asthma were recruited in the current study. Genotyping for various SNP associated due to the linkage disequilibrium patterns is to be performed. Genotypes would be statistically compared between patients with bronchial asthma and normal control subjects free of bronchial asthma

Interventions

GENETICSNP analysis of the DNA

SNP analysis of the DNA obtained from peripheral blood sample

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

5 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Persons with bronchial asthma confirmed by a doctor; * The age of the patients is from 5 to 60 years; * Persons of Kazakh nationality, whose paternal and maternal grandparents are Kazakhs. * Persons who are able and willing to provide written informed consent; * Persons capable and willing to comply with the research protocol;

Exclusion criteria

* Persons who, in the opinion of the researcher, are mentally or legally incapacitated, which prevents obtaining informed consent; * Pregnant or lactating women; * Tuberculosis of any localization in the active phase and in history; * Severe and decompensated diseases of the liver and kidneys, cardiovascular system; * Severe and decompensated course of endocrine diseases; * Autoimmune diseases; * Systemic diseases; * Oncological diseases;

Design outcomes

Primary

Measure	Time frame	Description
number of SNPs associated with bronchial asthma	1 year	Using SNPsto identify candidate genes associate with bronchial asthma

Countries

Kazakhstan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026