Desflurane and Anesthesia Recovery Period in Endonasal Endoscopic Pituitary Adenoma Resection

Effects of Desflurane on the Quality of Anesthesia Recovery Period in Patients Undergoing Endonasal Endoscopic Pituitary Adenoma Resection#a Randomized Controlled Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05088252

Enrollment

112

Registered

2021-10-21

Start date

2021-12-01

Completion date

2022-05-31

Last updated

2023-06-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pituitary Neoplasms

Brief summary

Nasal packing is required after endoscopic pituitary adenoma resection. The patient can only breathe through the mouth. The blood and secretion in the nasal cavity may be inhaled into the trachea after the operation. GH-secreting pituitary adenoma causes pharyngeal soft tissue and tongue hypertrophy. These conditions increase the risk of respiratory obstruction and hypoxemia during anesthesia recovery. Propofol total intravenous anesthesia has a rapid effect and a low incidence of nausea and vomiting. Patients anesthetized with desflurane recover quickly is conducive to early recovery of respiratory function and orientation. This study intends to compare the effects of desflurane and propofol on the quality of anesthesia recovery period in patients undergoing endonasal endoscopic pituitary adenoma resection and to provide clinical evidence for the use of desflurane in neurosurgical anesthesia.

Interventions

DRUGDesflurane

After induction, anesthesia will be maintained with 0.7-1.0 MAC desflurane and 0.05-0.3 μg/kg/min remifentanil.

DRUGPropofol

After induction, anesthesia will be maintained with 4-6mg/kg/h propofol and 0.05- 0.3 μg/kg/min remifentanil.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* 18-65 years; * Elective endoscopic transsphenoidal resection of pituitary adenomas; * ASA status I-III; * Informed consent signed by patients.

Exclusion criteria

* emergency surgery; * complicated with cerebrovascular disease; * complicated with pulmonary disease, oxygen saturation below 95% without oxygen; * expected to retain endotracheal intubation; * preoperative disturbance of consciousness was not compatible with assessment; * complicated with primary hypothyroidism; * previous history of cervical surgery, burns, and radiotherapy; * BMI \>30kg/m2; * invasive pituitary adenoma with Knosp grade 4.

Design outcomes

Primary

Measure	Time frame
Time required of the Aldrete score reached 9 points after drug withdrawal.	immediately after the surgery

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026