Fetal Growth Retardation
Conditions
Brief summary
Aim: In this study, pesticide and pharmaceutical contaminants levels in the placenta and cord blood of pregnant women with fetal growth retardation and healthy pregnant women will be compared in placenta and cord blood samples after delivery.
Detailed description
The study will be conducted with a total of 40 pregnant women, 20 of whom are in the control groups and those with FGR diagnoses. Cases in both groups will be matched in terms of demographic information. Demographic information (including socioeconomic status, educational level, region of residence), ultrasound and Doppler examination results, newborn weight at birth, APGAR score, gender, mode of delivery, whether there is a need for neonatal intensive care or not will be recorded.
Interventions
OTHER. Pesticide and Pharmaceutical analysis
Pesticide and Pharmaceutical analysis will be done with LC-MS/MS device.
Sponsors
Kutahya Health Sciences University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Between the ages of 18-40 years * Gestational age between 320/7 - 396/7 weeks * Singleton pregnancy * For the FGR group: estimated fetal weight \<10th percentile * For the control group: being healthy pregnant * Intact amniotic membrane
Exclusion criteria
* Multiple pregnancies * Cardiovascular disease * Chronic hypertension * Autoimmune disease * Intrahepatic cholestasis of pregnancy * Preeclampsia-eclampsia * Sepsis * Placenta accreta spectrum * Abnormalities of placenta * The chromosomal or congenital structural anomaly of the fetus * Smoking * BMI \>30 kg/m2
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pesticide and Pharmaceutical analysis | 1 year | Pesticide and pharmaceutical contaminants levels in pregnant women's placenta and cord blood will be measured in placenta and cord blood samples after delivery. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Multi logistic regression analysis. | 1 month | If there is a significant difference in other data, including the pesticide and pharmaceutical contaminants levels, in the FGR group, the effect of each factor on the development of FGR will be analyzed by multi logistic regression analysis. |
| ROC analysis | 1 month | If the pesticide and pharmaceutical contaminants levels is found to be significantly higher in the FGR group, the cut-off value will be obtained by ROC analysis. |
Outcome results
None listed