Atrial Fibrillation Ablation, Persistent Atrial Fibrillation
Conditions
Keywords
Oesophageal Pacing, Hybrid Ablation, Persistent Atrial Fibrillation
Brief summary
Patients undergoing hybrid AF ablation second stage catheter ablation have the posterior left atrium mapped to see it if is electrically isolated. This is done via a standard electrophysiogical study in accordance with routine clinical practice. Investigators propose to check left atrium posterior wall isolation via oesophageal pacing and compare this to findings from invasive study
Detailed description
Oesophageal temporary pacing of the heart is an established treatment in heart block and several catheters are licenced for this purpose with minimal procedural risks. Due to the position of the oesophagus, pacing from the oesophagus could sense and pace the posterior left atrium. If the posterior wall could be demonstrated to be electrically isolated with oesophageal pacing then invasive electrophysiological study such as the second stage of a hybrid AF ablation would be unnecessary. This would save patients from undergoing invasive left atrial mapping and exposure to the consequent risks of the procedure.
Interventions
DEVICEOesophageal pacing after left atrial posterior wall isolation
Following AF ablation with the aim of isolating the left atrial posterior wall oesophageal pacing and sensing is performed to check for left atrial posterior wall. entrance and exit block.
Sponsors
University Hospital Plymouth NHS Trust
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
• subjects capable of giving informed consent, * Male or female * Aged between 18 and 80 years * Undergoing ablation under general anaesthetic with planned isolation of the left atrial posterior wall or who have previously undergone either catheter or surgical ablation for AF with LA posterior wall isolation
Exclusion criteria
* Unable or willing to give fully informed written consent * Turned down for general anaesthetic * Pregnancy * Terminal illness * Any other significant disease or disorder which, in the opinion of the investigator, may either put the participant at risk because of participation in the study, or may influence the result of the study, or the participant's ability to participate.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Left atrial posterior wall isolation | Through study completion, an average of 4 years | Measured via invasive left atrial mapping |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Complication rate | Through study completion, an average of 4 years | Documentation of the number of complications caused by the oesophageal pacing procedure |
| Feasibility of using device | Through study completion, an average of 4 years | The success rate of left atrial posterior wall isolation. |
Countries
United Kingdom
Outcome results
None listed