Childhood Cancer
Conditions
Keywords
physical therapy, functional mobility
Brief summary
Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy, with the peak incidences occurring in children two to five years of age. Children with ALL received neurotoxic chemotherapy agents for two to three years that causes decreased distal muscle strength and poor timing of muscle activation. After completion of medical treatment, ALL childhood cancer survivors (ALL CCS) are more likely to have an inactive lifestyle, resulting in life-long gross motor proficiency differences compared to their peers. ALL CCS typically do not utilize physical therapists' expertise after medical treatment has been completed. There are limited physical therapy (PT) intervention studies for ALL CCS.
Detailed description
We are performing a feasibility study to examine a movement based intervention that utilizes fast movements through jumping rope to improve balance, coordination, movement speed, and movement agility. The abilities to generate fast movements are required to perform functional activities and for playing sports. Participants will receive five in-person PT sessions and a home program for six weeks. The goal of this research is to determine the feasibility, acceptability, and promise of a PT program that emphasizes fast movements in ALL CCS.
Interventions
BEHAVIORALJUMP
Warm-up, stretching, jumping rope, cool-down
Sponsors
University of Maryland, Baltimore
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Masking description
the physical therapist performing the baseline and post-training does not have involvement with the intervention
Intervention model description
Feasibility study
Eligibility
Sex/Gender
ALL
Age
6 Years to 17 Years
Healthy volunteers
No
Inclusion criteria
* Children 6-17 years old * Completed medical treatment for ALL within the past five years (1 to 60 months) * Speak English.
Exclusion criteria
* Diagnosis of a neurological disorder such as cerebral palsy, Down syndrome * Currently receiving PT services.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Gross Motor Proficiency | 20 minutes | Bruininks-Oseretsky Test of Motor Proficiency 2nd edition (BOT-2) (subtest 4, 5, 6, 8: bilateral coordination, balance, running speed and agility, and strength). The BOT-2 is a reliable and valid norm-referenced instrument designed for children and adolescents 4-21 years old. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| electromyography (EMG) | 5 minutes | The EMG onset will be defined by the time when the EMG burst is 3 standard deviations above the baseline muscle activity. The slope of the muscle activity, which is the linear regression line of best fit for the values between the onset of the EMG, and the peak of the EMG burst amplitude will be calculated and normalized by dividing the slope by the peak amplitude. The EMG burst slope reflects the recruitment and firing rate of motor units at the onset of the contraction, which is important for producing fast responses. |
| Preferences for Physical Activity for Children (PAC) | 10 minutes | This is a survey to explore physical activity preferences of children. |
| Children's Assessment of Participation and Enjoyment (CAPE) questionnaire. | 10 minutes | The CAPE are designed for use with children ages 6-21 years old. |
| Peak vertical ground reaction | 5 minutes | participant is asked to jump on the force platform. Takeoff is defined as the highest vertical ground reaction force value attained from the force time record for the takeoff phase of each jump, minus body mass |
| Motion Capture Analysis | 5 minutes | The 3D motion analysis will be captured with a VICON T10 Camera with Nexus Software VICON markers will be placed on each shoe in the position of the great toe, ankle (lateral malleoli), lateral knee (proximal to the apex of the fibular head), greater trochanter of the hip, shoulder (greater tubercle of the humerus), lateral elbow (distal to lateral epicondyle), the wrist (styloid process), and head (wearing a headband). |
| Vertical Jump Height | 5 minutes | Participants will perform five vertical jumps starting in the upright standing position with their feet on two adjacent force platforms. The instructions will be to jump straight up as high as you can. |
Countries
United States
Outcome results
None listed