Stroke
Conditions
Keywords
Rehabilitation
Brief summary
Multimodal imaging of stroke patients. Patients included in the study will be investigated with multiparametric imaging tools including MRI and EEG imaging. Improvements in motor skills will be monitored clinically.
Detailed description
We aim to (i) quantify the size of the brain lesion and assess the surviving functional neural network connections; (ii) Analyze the type and degree of inflammation initiated by the stroke-induced brain lesion. We will stratify inflammation according to lesion volume, surviving functional neural network connections, age, NIHSS and Modified Rankin Scale (mRS) and analyze how inflammation markers change during rehabilitation; (iii) Train the surviving neural network to create new synaptic connections that can maximize restoration of motor functions; (iv) Apply and develop advanced mathematical and computational methods to model and predict how stroke rehabilitation can rewire the neural network connections to best facilitate restoration of lost motor function.
Interventions
BEHAVIORALKinematic movement analysis
moving arm/leg while registration with electromyography, electroencephalogram, accelerometers, functional near infrared spectroscopy and 3 dimensional video registration of hand, arm, foot and leg movements.
Sponsors
St. Olavs Hospital
OsloMet
Norwegian University of Science and Technology
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* subcortical strokes resulting in arm motor deficits. * admitted to the stroke unit, St Olav´s Hospital during 2021-2023
Exclusion criteria
* Previous stroke * neurodegenerative disease * brain tumors * previous neurotrauma or brain operation * aphasia * cognitive dysfunction and claustrophobia preventing MRI examinations.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in brain volume | 6 months | Stroke induced brain volume changes (mm3) will be measured using magnetic resonance imaging (MRI) at 1 day and 6 months post-stroke. |
| Stroke induced changes in brain activity. | 6 months | Document longitudinal changes in brain activity using EEG. Changes will be measured in cycles/second (Hertz, Hz). |
| Changes in inflammatory activity in brain | 6 months | Markers of post-stroke inflammation will be measured in pg/ml and ng/ml. |
| muscle function | 6 months | Longitudinal kinematic profiling. Electromyography measurements of muscle function post-stroke will be measured in cycles/second (Hz) and amplitude (mm). Extension and flexion of arm will be measured in cm. Joint angles will be measured in degrees. Speed of flexion and extension will be measured in cm/second |
Countries
Norway
Contacts
Primary ContactAxel Sandvig, PhD ass prof
Outcome results
None listed