Critical Illness, Hypernatremia
Conditions
Brief summary
Hypernatremia is frequently encountered in patients admitted to the Intensive Care Unit (ICU) and associated with increased mortality and length of stay. Previous studies focused on predictors in the development and recovery of hypernatremia by including amount and types of administered medication, fluid balance, laboratory results and changes in vital signs. However, data of larger populations or data on infusion rates, fluid and sodium balance or renal replacement therapy is lacking. The predecessor of this study was the HYPNIC trial which found that increased sodium load en decreased sodium excretion preceded hypernatremia development, but was lacking information on the first 48 hours, fluid balances were manually collected before a new data collection system was introduced and was suffering from substantial amounts of missing data and small population for trend analysis. This study aims to provide better insight in the development and recovery of hypernatremia while paying attention to the limitations from the HYPNIC trial.
Interventions
OTHERDaily urine collection for biochemical analysis
For every patient in ICU, a daily morning urine sample will be collected from the already collected urine via catheter.
OTHERSubanalysis for comparison of 24hour urine collection versus spot-check measurements
For a subgroup of 30 sedated patients, 24 hour urine collection will be collected. In addition, every 2 hours a 10ml urine sample will be collected.
Sponsors
Catharina Ziekenhuis Eindhoven
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Admitted to Intensive Care Unit * Age 18 years or older
Exclusion criteria
* Age 17 years or younger
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hypernatremia | During admission in ICU | After one year of collecting data on fluid and sodium balances, the patients who developed hypernatremia during their admission in the Intensive Care Unit will be compared to the patients who remained normonatremic throughout their ICU admission. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 24 hour urine replacement for spot-checks | 24 hours | Assessing whether 24 hour urine collection can be replaced by spot-check measurements of urine by comparing both 24 hour urine and 2 hourly urine samples |
Countries
Netherlands
Contacts
Primary ContactEveline Mestrom, MD
Backup ContactJonna van der Stam, MSc
Outcome results
None listed