Feasibility and Prognosis of Early Rehabilitation in Patients With ECMO

Feasibility and Prognosis of Early Rehabilitation in Patients With Extracorporeal Membrane Oxygenation

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05083624

Enrollment

100

Registered

2021-10-19

Start date

2021-12-01

Completion date

2022-11-30

Last updated

2021-10-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Extracorporeal Membrane Oxygenation

Keywords

Extracorporeal Membrane Oxygenation, early rehabilation, muscle ultrasound

Brief summary

ECMO is increasingly used in critically ill patients with severe circulatory and/or respiratory failure. Because of the catheterization of the femoral artery and femoral vein, usage of sedatives, and occasionally with neuromuscular blockers, ECMO patients are generally considered unsuitable for early activity. However, some recent retrospective studies and a small number of single-center, small-scale prospective studies have shown that early activity of ECMO patients is feasible, and early active activity is associated with recovery of independent function and reduction of delirium incidence.

Interventions

BEHAVIORALrehabilation therapy

After comprehensive assessment by doctors, nurses and rehabilitation therapists, patients gradually begin rehabilitation treatment.IMS 0: no mobilisation or passively exercised by staff. IMS 1: sitting in bed and actively exercising .IMS 2: passively moved to chair without standing.IMS 3: sitting over edge of bed.IMS 4: standing in front of bed.IMS 5: transferring bed to chair.IMS 6: marching on spot.IMS 7: walking with assistance of more than one person.IMS 8: walking with assistance of one person.IMS 9: walking independently with a gait aid.IMS 10: walking independently without a gait aid.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* ECMO time ≥1 day * Aged older than16 years old and less than 70 years old

Exclusion criteria

* coma deep * sedation muscle relaxation (RAAS-3-5) * Active bleeding deep vein thrombosis * High dose of vasoactive drugs * unstable vital signs * Acute stage of myocardial infarction (within 2d) * Malignant arrhythmia * pregnancy

Design outcomes

Primary

Measure	Time frame	Description
muscle ultrasound	7 days	The thickness of intercostal muscle and rectus femoris muscle was measured by ultrasound

Secondary

Measure	Time frame
ECMO duration time	30 days

Countries

China

Contacts

Primary ContactJinyan Xing, Doctor

xingjy@qdu.edu.cn86-0532-82919386

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026