Multicentre ObseRvational Study in Posterior mecHanical thrombEctomy: conscioUs Sedation vs General aneSthesia

Multicentre ObseRvational Study in Posterior mecHanical thrombEctomy: conscioUs Sedation vs General aneSthesia: MORPHEUS STROKE REGISTRY

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05082896

Enrollment

453

Registered

2021-10-19

Start date

2021-01-01

Completion date

2023-06-30

Last updated

2024-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Conscious Sedation, General Anesthesia, Mechanical Thrombectomy, Posterior Circulation

Brief summary

The association of conscious sedation vs. general anesthesia in ischemic stroke with posterior circulation occlusions undergoing endovascular therapy, is istill unknown. No prospective or clinical trials have studied this effect on posterior circulation strokes. The choice of anesthetic regimen is ussually depending on local stroke-team protocols or neurointerventional preference. MORPHEUS Stroke Registry is a prospective multicentre observational study that investigates the association between anestheisa and functional outcome in patients with posterior circulation large vessel occlusion treated endovascularly.

Interventions

PROCEDUREType of anesthesia choice

Use of conscious sedation vs. general anesthesia

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* Subject aged ≥ 18 years * Evidence of posterior arterial occlussion (basilar artery, intracranial vertebral artery and posterior cerebral artery) * Patients eligible for mechanical thrombectomy

Exclusion criteria

* Patient's refusal to participate * Arterial recanalization prior to endovascular thrombectomy attempt * Patient unable to present or be available for follow-up

Design outcomes

Primary

Measure	Time frame	Description
Functional independence at 3 months	3 months	Rate of functional independence (modified Rankin Scale 0-2) at 3 months

Secondary

Measure	Time frame	Description
Mortality	3 months	Rate of mortality at 3 months
Successfull recanalization and complete recanalization according to endovascular technique	1 day, revascularization grade will be assessed	Rate of mTICI 3 and mTICI 2b-3 according to endovascular technique (contact aspiration, stentriever or combined)
Number of passes	1 day, number of device passes will be assessed	Number of intracranial thrombectomy passes to achieve final reperfusion
NIHSS at 24 hours	24 hours	Rate of neurological status at 24 hours, dramatical neurological improvement after mechanical thrombectomy
First Pass Effect	1 day	Rate of complete successful recanalization (mTICI 2c-3) with one single pass of device
Length of stentretriever and recanalization	1 day, stentretriever type will be assessed	Rates of FPE and succesful recanalization according to the length of stentretriever used
Arterial hypotension during anesthesic induction and outcome	3 months	Study of arterial hypotension during anesthesic induction and outcome
Bridging therapy and neurologial/functional outcomes	1 day, type of previous fibrinolytic use will be assessed	To study the association between bridging therapy and reperfussion rates, neurological status and funtional independence at 3 months.
Type of anesthesic and outcome	3 months	Study of the type of anesthesic choice and complications, time of intubation and

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026