Cardiovascular Diseases, Retina; Change
Conditions
Keywords
retinal vasculature, cardiovascular disease, swept source optical coherence tomography angiography, SS-OCTA, carotid duplex ultrasonography
Brief summary
This study aims to determine whether changes in retinal vasculature seen on SS-OCTA can be correlated to degree of cardiovascular disease as measured by carotid duplex ultrasonography.
Detailed description
The study's primary objective is to determine whether measures taken from SS-OCTA, color fundus photography, and retinal exams can correlate with and predict the presence/degree of carotid occlusive disease as determined by carotid duplex ultrasonography by examining the following parameters: retinal vessel caliber, retinal vessel density, retinal vessel perfusion, retinal vessel tortuosity, presence of Hollenhorst or other plaques, and/or areas of ischemia.
Interventions
DIAGNOSTIC_TESTSwept Source Optical Coherence Tomography Angiography
The PLEX Elite 9000 is an FDA cleared research device for use in ocular imaging obtained by Northwestern University by way of a purchase agreement with the manufacturer, Carl Zeiss Meditec, Inc. It is currently unavailable outside of participation in the ARI Network, a cloudbased storage and image processing platform using deidentified information shared between academic institutions. The ARI Network is managed by a group of physicians and scientists from around the world that are working to better understand eye diseases.
Sponsors
Northwestern University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 95 Years
Healthy volunteers
Yes
Inclusion criteria
* Subjects between 18 and 95 years of age * Able to participate in a clinical eye examination setting * Able to consent * Subjects receiving standard of care carotid duplex ultrasounds
Exclusion criteria
* Inability to get high quality imaging for any reason (ex. Dense cataract, media opacity) * Lack of capacity to provide informed consent * Subjects younger than 18 years of age or older than 95 years of age * History of stroke or acute loss of vision * Unable to participate in a clinical eye examination setting
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation with and prediction of the presence/degree of carotid occlusive disease as determined by carotid duplex ultrasonography | 2 hours | Determining whether measures taken from SS-OCTA, color fundus photography, and retinal exams can correlate with and predict the presence/degree of carotid occlusive disease as determined by carotid duplex ultrasonography by examining the following parameters: retinal vessel caliber, retinal vessel density, retinal vessel perfusion, retinal vessel tortuosity, presence of Hellenhorst or other plaques, and/or areas of ischemia. |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORRukhsana Mirza, MD
Northwestern University
Outcome results
None listed