Tourniquets
Conditions
Keywords
thiol/disulfide homeostasis, ischemic preconditioning
Brief summary
Various strategies have been proposed to prevent or mitigate the effects of ischemia-reperfusion injury following the use of tourniquets in orthopedic surgery cases. One of them is applying remote ischemic preconditioning. This randomized controlled trial is planned to evaluate the effectiveness of remote ischemic preconditioning in preventing tourniquet-induced ischemia-reperfusion injury in total knee arthroscopy with dynamic thiol-disulfide homeostasis.
Interventions
OTHERRemote Ischemic Preconditioning
Three cycles of 5-min upper limb ischemia and 5-min reperfusion using a blood-pressure cuff inflated to a pressure of systolic blood pressure plus 50 mm Hg.
OTHERsham group
a deflated cuff placed on the upper arm for 30 min
Sponsors
Konya Meram State Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* ASA I-III patients who will undergo total knee arthroplasty surgery under elective conditions
Exclusion criteria
* emergency operation, * Underlying neurological disorder, * Underlying peripheral vascular disease, * other types of concurrent surgery.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| thiol/disulfide homeostasis | 24th hour after surgery | Thiol/disulphide homeostasis will be determined at preoperatively and just before the tourniquet opened and at the 1st, 6th and 24th hours after the tourniquet is opened. |
Countries
Turkey (Türkiye)
Outcome results
None listed