Hip Fractures, Magnetic Resonance Imaging, Postoperative Delirium
Conditions
Keywords
older people, postoperative delirium, Functional MRI
Brief summary
An assessment of the feasibility of structural and functional magnetic resonance imaging (MRI) brain scans in older people who have recovered from and older people who never had delirium after hip fracture surgery
Detailed description
Postoperative delirium, an acute sate of confusion occurs with higher frequency in older people. Hip fracture surgery is a procedure associated with an increased risk of postoperative delirium. In the study the feasibility of achieving structure and functional connectivity imaging of the brain, using magnetic resonance imaging, in older people who are recovering from hip fracture surgery will be assessed. People who have recovered from post operative delirium and people who did not have postoperative delirium will be included.
Interventions
DIAGNOSTIC_TESTFunctional MRI
Series of MRI scans of the brain
Sponsors
University of Nottingham
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Age * Age ≥ 65 years * Cognitively intact * primary admission for hip fracture surgery
Exclusion criteria
* Cognitive impairment * Less than moderate level of activities of daily living * History of neurosurgery/significant head trauma * Acutely unwell/moribund * Presence of neurological diseases including overt stroke, dementia, multiple sclerosis, Parkinson's disease, intracranial tumours and other significant neurologic disorders. * Postural or movement disorders likely to impede MRI scan * Contraindications to MRI * Complex fractures/multiple injuries
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Feasibility of MRI in older people following hip fracture surgery assessed by tolerability of transfer to scanner and the scanning process | From time of consent to day after MRI scan which is up to 5 days | The feasibility of transferring participants to and achieving structural and functional MRI scans. Specifically we will assess the number of participants in whom scans were successfully achieved |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Abnormalities of functional connectivity | Up to one month after scans have been achieved | Identify any differences in functional connectivity between the resolved delirium and the never delirium MRI scans |
| Pain assessment. | From immediately prior to transfer to the MRI suite until return to own hospital bed which is approximately 2 hours | An assessment of baseline pain levels and then repeat assessments of pain during transfer and the MRI scanning process using the numerical pain rating scale |
| Actual times taken to achieve scans | Up to 60 minutes | An assessment of unforeseen constraints on time taken to scan |
| Participant feedback | Two occassions. The first immediately after return from the MRI scan suite. The second will occur the day after scanning. Each will take 5 minutes. | The participant experience will be explored via verbal feedback which will be documented by the accompanying researcher |
Contacts
Primary ContactAbiodun Moronke Noah, FRCA
Backup ContactIain K Moppett, DM
Outcome results
None listed