Muscle Loss
Conditions
Keywords
Skeletal muscle
Brief summary
The study investigates effects related to muscle protein metabolism at provision of Parenteral or enteral nutrition
Detailed description
Randomized study investigation alterations in muscle protein metabolism at provision of parenteral or enteral (oral drink) nutrition. The study uses a genomic/transcriptomic/proteomic approach to evaluate factors related to activation of skeletal muscle protein synthesis and protein degradation. Patients scheduled for major gastrointestinal surgery are included. Muscle specimens are collected during surgery.
Interventions
DIETARY_SUPPLEMENTEnteral nutrition
Oral nutrition drink. 2 \* 200 ml on the night before operation. 1\* 200 ml on the morning of operation day.
OTHERControl
Overnight infusion of crystalloid fluid (Ringer acetate) infused at the same rate (ml/kg) as intervention PN
DIETARY_SUPPLEMENTParenteral nutrition (PN)
Overnight infusion of parenteral nutrition. Supplied as all-in-one-bag format. Infusion rate of 0.2 g N/kg/day.
Sponsors
Göteborg University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Outcomes Assessor)
Masking description
Persons responsible for genomic/transcriptomic/proteomics analyses are blinded. All samples are coded.
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Major gastrointestinal surgery. * Assumed need of post-operative nutrition support.
Exclusion criteria
* Insulin dependent diabetes. * Steroid medication.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Muscle protein metabolism | ~12-14 hours. | Alterations in skeletal muscle gene expression quantified by microarray |
Countries
Sweden
Outcome results
None listed