Healthy Volunteer
Conditions
Keywords
Tractography, DTI, MRI, spinal cord
Brief summary
Today, Spinal cord pathologies, whether are tumoral, vascular, traumatic, malformative, inflammatory, or degenerative still constitute a major medico-surgical challenge due to the particular anatomy of the spinal cord. Indeed, the spinal fibers (whether they have a sensory or motor function) are all condensed in an extremely small volume. To date, there is no reliable technique to know the precise position of the spinal tracts specifically involved in the sensory and motor functions of the upper and lower limbs. The purpose of this study is to evaluate the feasibility for differentiating spinal tracts by tractography from a cerebral Diffusion tensor imaging (DTI) Magnetic Resonance Imaging (MRI) sequence (associated with an anatomical sequence) by performing a stitching process with spinal cord DTI MRI sequence, in healthy subjects. The criterion of differentiation of the tracts will be assessed by highlighting already known cerebral tracts (cortico-spinal fibers, spinothalamic, posterior cord) and which will be monitored at the spinal level.
Interventions
PROCEDURESpinal cord Tractography in order to differentiate spinal tracts.
Spinal cord tractography using DTI MRI sequences of the brain and spinal cord, in order to differentiate tracts at the spinal cord level; and by performing a stitching process between Brain and Spinal cord DTI sequences.
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* patient\> 18 years old * Healthy volunteer * Social insured in France * Patient who signed the informed consent of the study
Exclusion criteria
* Medical or surgical history of disease that may affect the central nervous system, or the spine * History of spine or spinal cord trauma. * Spinal osteoarthritis which can lead to a medullary hyper signal. * Contraindication to MRI: claustrophobia, pace-maker, defibrillator, metallic foreign bodies, etc. * Subjects benefiting from legal protection (curatorship, guardianship or safeguard of justice). * Pregnant and / or breastfeeding woman.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Spinal tracts differentiation and identification | date of Tractography procedure (DTI MRI) | Percentage of complete tracts identified among healthy volunteer |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Spinal cord Tracts Atlas | 12 months (end of recruitment and exams) | Elaboration of a tracts classification using a algorithm based on the type, the volume and the fraction of anisotropy and mean diffusivity of each tract |
Countries
France
Outcome results
None listed