Endoscopic Versus Radiologic Biliary Drainage for Perihilar Malignant Obstruction

Comparison of Efficacy and Safety of Endoscopic Biliary Drainage and Percutaneous Transhepatic Biliary Drainage for the Management of Perihilar Malignant Biliary Obstruction: a Monocentric Retrospective Study

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05078801

Enrollment

100

Registered

2021-10-15

Start date

2021-07-15

Completion date

2022-10-30

Last updated

2021-10-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Jaundice, Obstructive, Perihilar Cholangiocarcinoma

Keywords

ERCP, EUS-guided biliary drainage, Percutaneous transhepatic biliary drainage, hilar obstruction

Brief summary

This retrospective monocentric study aims at comparing multimodality endoscopic biliary drainage versus percutaneous radiologic biliary drainage in case of perihilar malignant obstruction. Data from patients admitted in the Nancy University Hospital, France, between january 2016 and march 2022 with jaundice and perihilar obstruction will be retrospectively collected.

Interventions

PROCEDUREEndoscopic drainage

ERCP and/or EUS-guided biliary drainage

PROCEDUREPercutaneous transhepatic biliary drainage

US or CT-guided percutaneous drainage

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* hospitalization between january 2006 and march 2022 * perihilar obstruction * indication of biliary drainage

Exclusion criteria

* distal biliary obstruction * perihilar obstruction without indication of biliary drainage

Design outcomes

Primary

Measure	Time frame	Description
Bilirubin serum level	7 days	Diminution of 20% of more on day 7 of the bilirubin serum level

Secondary

Measure	Time frame	Description
Complications	16 years	complication-free survival
number of procedures	16 years	total number of procedures, including all endoscopic and radiological interventions
bilirubin serum level on day 30 and on day 90	90 days	—
median survival in months	16 years	median survival in month in each group
number of unplanned hospital admissions	16 years	total number of unplanned hospital admissions (for unplanned biliary drainage, cholangitis or other complications...)

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026