Holmium Laser Uretherotomy in Combination With Intralesional Steroids in Bulbar Uretheral Stricture

Efficacy of Holmium Laser Uretherotomy in Combination With Intralesional Steroids in the Treatment of Bulbar Uretheral Stricture

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05078788

Enrollment

124

Registered

2021-10-15

Start date

2020-06-02

Completion date

2021-09-10

Last updated

2021-10-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Urethral Stricture

Brief summary

the purpose is to evaluate the outcome of visual internal uretherotomy with Holmium laser along with intralesional steroid injection.

Detailed description

In this study, the investigator evaluates the efficacy of Holmium laser in combination with intra lesional steroid injection in the treatment of bulbar urethral strictures

Interventions

PROCEDURELaser uretherotomy

Holmium YAG Laser with pulse energy from 1-2 Joule, frequency from 10-15 Hertz and total power from 3.0 to 30.0 Watt were set up, respectively, based on the extent of the lesions. Scar tissue was incised at the position of 12-o'clock under the guidance of guidewire or ureteric catheter till fresh mucosa appeared.

PROCEDURELaser uretherotomy with triamcinolone

After laser urethrotomy, 80 mg of triamcinolone (diluted with normal saline to 10 ml) will be injected by using an injection needle (5 F size and 23 G needle size) at 10 sites, 1 ml each, along the site of urethrotomy and circumferentially.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Caregiver)

Eligibility

Sex/Gender

MALE

Age

26 Years to 69 Years

Healthy volunteers

Inclusion criteria

1. Presence of obstructive symptoms, 2. Short segment strictures (stricture length \<2 cm) as evident on radiological studies, i.e. retrograde urethrography and micturating cystourethrography. 3. Peak flow rate on uroflowmetry less than 15 ml/s

Exclusion criteria

1. Complete obliteration of lumen of urethra on urethroscopy, 2. Balanitis Xerotica Obliterans, 3. Age less than 18 years, 4. Multiple strictures, 5. Active urinary tract infection, 6. Recurrent Strictures. 7. Prior internal uretherotomy 8. Prior urethroplasty 9. Pan-anterior urethral strictures 10. Posterior stenosis 11. Those who lost to follow up

Design outcomes

Primary

Measure	Time frame	Description
the maximum flow rate (Qmax) is >15 ml/s at 3 and 6 months after procedure	3 and 6 months	The procedure will be accepted as successful when the maximum flow rate (Qmax) is \>15 ml/s.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026