Enhancing Memory in Mild Cognitive Impairment and Early Stage Alzheimer's Disease

Modern Energetic Methods of Response Improvement (MEMORI)

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05077826

Acronym

MEMORI

Enrollment

Registered

2021-10-14

Start date

2021-10-07

Completion date

2023-04-30

Last updated

2024-03-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alzheimer Disease, Mild Cognitive Impairment

Keywords

Dementia, Memory, Transcranial direct current stimulation (tDCS), Magnetic resonance imaging (MRI)

Brief summary

The investigators have developed a low-risk transcranial Electrical Stimulation (tES) treatment that has improved learning and performance in young adults up to nearly 4 times when compared with a sham control. This randomized pilot trial will determine if this same tES protocol improves memory in older adults (50-90 years old) who are healthy, and separately in older adults with mild cognitive impairment (MCI) or early stage Alzheimer's disease (AD). TES will be applied to the right temple and left arm for up to 40 minutes. MRI images, along with other measures, may be obtained before and after tES. If effective, this intervention may help to improve the quality of life for AD patients and their families.

Interventions

DEVICENorth Coast Medical Activadose II

tES device model Activadose II (North Coast Medical, Morgan Hill, CA, USA) programed to deliver tES.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

50 Years to 90 Years

Healthy volunteers

Yes

Inclusion criteria

Inclusion criteria for healthy participants: 1. 50-90 years of age, as verified via photo identification with date of birth. 2. Should be right-handed and learned English by seven years old. 3. Generally healthy Inclusion criteria for participants with MCI or AD: 1. 50-90 years of age, as verified via photo identification with date of birth. 2. Should be right-handed and learned English by seven years old. 3. Is legally able to sign the consent form on their own behalf, or has a legally authorized representative that is able to sign. 4. Has a caregiver that can assist with taking health history.

Design outcomes

Primary

Measure	Time frame	Description
Learning Task Performance	Within one hour after treatment	Performance accuracy on a complex visual learning and categorization task after full-current tES in comparison to partial-current tES.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026