Biomarkers, TCM Body Constitution, Dietary Pattern and Psychological Factors in Predicting Depression

Biomarkers, Traditional Chinese Medicine Body Constitution, Dietary Pattern and Psychological Factors in Predicting Depression Among University Students in UTAR, Malaysia

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05076643

Enrollment

397

Registered

2021-10-13

Start date

2022-03-17

Completion date

2024-12-31

Last updated

2024-08-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression

Brief summary

This study aims to determine the predictors of depression among university students in Universiti Tunku Abdul Rahman (UTAR) Sungai Long Campus.

Detailed description

University students are a high at risk group for development of depression. Identifying the determinants of depression could help in the diagnosis and treatment of this disorder. This study will incorporate questionnaire and blood sample data collection procedures on 397 subjects. Written consent will be obtained from the subjects. Eligible subjects will be given self-administered questionnaires which include Patient health questionnaire (PHQ-9), Constitution in Chinese medicine questionnaire (CCMQ), Dysfunctional Attitude Scale (DAS), Depression Anxiety Stress Scales (DASS-21) - stress and anxiety subscales, Perceived stress scale-10 (PSS-10), Rosenberg self-esteem scale (RSES), and Food frequency questionnaire (FFQ). Once the subjects completed the questionnaires, blood samples will be collected from them by a trained phlebotomist. In addition, 10 most high at risk of depression subjects (with PHQ-9 scores 10 and above) and 10 healthy subjects (with PHQ-9 scores lower than 10) will be selected randomly for protein expression to further identify the proteins that significantly expressed among them.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 30 Years

Healthy volunteers

Inclusion criteria

* Malaysian citizen * Able to read and communicate in English

Exclusion criteria

* Special education disability (deaf and blind) * Physical support * History of infectious diseases

Design outcomes

Primary

Measure	Time frame	Description
Genetic, TCM body constitution, psychological factors and dietary pattern are significant predictors for depression among university students.	Baseline	Univariate and multivariate logistic regression will be performed.

Secondary

Measure	Time frame	Description
Prevalence of depression among university students.	Baseline	Patient Health Questionnaire (PHQ-9): Non depressed = 0 - 9; Depressed = 10 - 27
Protein significantly expressed between depressed and non-depressed students.	Baseline	Liquid chromatography-mass spectrometry (LC-MS) will be performed.

Countries

Malaysia

Contacts

Primary ContactChai Nien Foo

foocn@utar.edu.my+60123167252

Outcome results