Polycystic Ovary Syndrome
Conditions
Brief summary
We aimed this study to determine and compare frequency of induction of ovulation in women with polycystic ovarian syndrome treated with Letrozole versus clomiphene citrate as published literature shows variations.
Detailed description
Discrepancy between ovulation induction rate and pregnancy rate is related to anti-estrogenic effects on cervical mucus and endometrium and long acting gonadotrophins are more effective than clomiphene citrate. This study was aimed at comparing frequency of induction of ovulation in women with polycystic ovarian syndrome treated with Letrozole versus clomiphene citrate.
Interventions
DRUGLetrozole
Letrozole as 5mg from day 3 to 7 of menstrual cycle
Sponsors
Nishtar Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Randomized controlled trial
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Diagnosed cases of polycystic ovarian syndrome.
Exclusion criteria
* All women having endocrine disorders like thyroid disorders. * Women having hyperprolactinemia.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Induction of ovulation was assessed by Transvaginal scan (TVS) | 12 to 16 days. | Induction of ovulation was assessed by TVS. If follicle of \>2cm is found on 12 days TVS and smaller/collapsed on 16 days TVS, ovulation induction was labeled |
Countries
Pakistan
Outcome results
None listed