Living Kidney Donation
Conditions
Keywords
living kidney donors, endothelial function, vascular remodeling, pulse wave velocity, glomerular filtration rate
Brief summary
Vascular evaluation of candidates to living kidney donation is important because there is an increased risk of end stage renal disease and cardiovascular disease after donation. The implication of vascular remodeling in the vascular morbidity observed in donors has not been established because the parameters of vascular remodeling in donors have so far been poorly described. The object of the present study is to study the evolution of vascular remodeling of small, medium and large vessels (until then not evaluable by standard techniques) before and one year after living kidney donation, by dedicated-, non invasive-examinations, which results are associated with cardiovascular risk in the general population. This approach will make it possible to precisely assess the impact of unilateral nephrectomy on vascular remodeling after living donation and to estimate the change in cardiovascular risk attributable to the donation. These results will also help refine the assessment of candidates for kidney donation and potentially open up new strategies to improve selection process of candidates to living kidney donation. Of note, we also plan to evaluate one year after the first exploration potentiel living kidney donors who did not give their kidney due to medical or non medical reasons, as a control group.
Interventions
DIAGNOSTIC_TESTVascular remodeling characterization
Pulse wave velocity measure High frequency ultrasonography for vascular imaging Endothelial function test Left ventricular mass by echocardiography Measurement of GFR (Glomerular Filtration Rate) with decrease in plasma of Iohexol
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* candidate to living kidney donation * affiliated to national health insurance * capable of understanding the consequences of participating to the study * written informed consent
Exclusion criteria
* pregnancy * breastfeeding * allergy to iodinated contrast agents * allergy to echographic gel, allergy to cutaneous dressings * cutaneous lesions preventing the ultrasonography probe to be applied on the skin * participation to a drug trial
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Carotid artery rigidity | 1 year after living kidney donation or after the first exploration for the non donors | Carotid stiffness, as measured by echotracking |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Measured glomerular filtration rate | 1 year after living kidney donation or after the first exploration for the non donors | — |
| Pulse wave velocity | 1 year after living kidney donation or after the first exploration for the non donors | — |
| Endothelial function | 1 year after living kidney donation or after the first exploration for the non donors | Measured Glomerular Filtration Rate (urinary clearance of 99mTc-DTPA) unit: ml/min/1,73 m² |
| Small arteries remodeling | 1 year after living kidney donation or after the first exploration for the non donors | — |
Countries
France
Contacts
Primary ContactMarie COURBEBAISSE, MD, PhD
Backup ContactNatacha NOHILE
Outcome results
None listed