Parkinson Disease
Conditions
Keywords
Attention, NIRS, Gait, Prefrontal cortex, Parkinson's disease
Brief summary
Attention may influence the motor performance and frontal activity. This study will examine the effect of different attentional focus: internal, external and divided attention (dual task) on prefrontal cortical activation (fNIRS) and on gait performance. Thirty older adults and thirty PD will participate in this study.
Detailed description
The subjects will be guided to walk at a normal pace while maintaining the required attentional focus. Subjects will walk on 20 m four times in each of the four different focus conditions : 1. no instructions about the attentional focus 2. internal focus on their feet movements, 3. external focus on two lines drawn on the floor, 4. divided attention (walking while performing an arithmetic task). A fNIRS system will be used for the prefrontal cortex activation evaluation and FeetMe soles for gait analyses.
Interventions
The hemodynamic response in prefrontal cortex will be measured using an Octomon+ system (Artinis). Eight emission and two detector probes will be arranged on the participant's forehead.
Sponsors
Centre Hospitalier Régional d'Orléans
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
60 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* For 2 groups : * Man or woman 60-85 years old * Informed consent obtained * Group Parkinson : clinical diagnosis of idiopathic Parkinson's Disease, according to the UK Brain Bank criteria.
Exclusion criteria
* For 2 groups : * Assisted walker * Neurological (other than those resulting from Parkinson's disease), cardiologic, rheumatologic disorders * Disorders affecting gait. * Montreal Cognitive Assessment (MOCA) \< 24. * Concomitant medication likely to interfere with the results. * Group Parkinson: * freezing * Hoehn et Yahr \> III
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effects of oxyhemoglobin variations on hemodynamic response in prefrontal cortex | Baseline | Oxyhemoglobin variations in prefrontal cortex will be measured with a fNIRS system, on a 20 meters distance. |
| Effects of deoxyhemoglobin variations on hemodynamic response in prefrontal cortex | Baseline | Deoxyhemoglobin variations in prefrontal cortex will be measured with a fNIRS system |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effects of speed on gait. | baseline | Gait parameters will be measured with connected soles FeetMe ® : speed |
| Effects of cadence on gait. | baseline | Gait parameters will be measured with connected soles FeetMe ® : cadence |
| Effects of stride length on gait. | baseline | Gait parameters will be measured with connected soles FeetMe ® : stride length |
| Effects of double support time on gait. | baseline | Gait parameters will be measured with connected soles FeetMe ® : double support time. |
Countries
France
Outcome results
None listed