Cesarean Section Complications
Conditions
Brief summary
twin pregnant women requesting cesarean section, the effectiveness and safety of temporary uterine packing coupled with topical tranexamic acid as an adjuvant for decreasing blood loss during delivery were compared to placebo.
Detailed description
The most common cause of postpartum hemorrhage (PPH) is uterine atony, which accounts for up to 80% of PPH occurrences. PPH is the main cause of maternal morbidity and mortality, accounting for up to 28% of all maternal deaths globally. As a result, generating a fast and efficient uterine contraction after birth is critical. Obesity, White or Hispanic race/ethnicity, polyhydramnios, preeclampsia, anemia, and chorioamnionitis, as well as a twin pregnancy, are all risk factors for uterine atony.
Interventions
temporary uterine packing with gauze of the dimensions soaked with 2 gm tranexamic diluted in 60ml saline acid
OTHERnormal saline
temporary uterine packing with gauze of the dimensions soaked with 2 gm placebo to tranexamic diluted in 60ml saline acid
Sponsors
Aswan University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Masking description
a double-blind randomized controlled study
Intervention model description
a double-blind randomized controlled study
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* Women With Twin Pregnancy Undergoing Cesarean Section
Exclusion criteria
* Patients with cardiac, hepatic, renal, or thromboembolic disease. , * patients with a high possibility of the morbid adherent placenta, * known coagulopathy and * those presented with severe antepartum hemorrhage * refuse to participate
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| intraoperative blood loss | 30 minutes | measurement the intraoperative blood loss by direct and gravimetric methods |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| postoperative blood loss | 12 hours | measurement the intraoperative blood loss by direct and gravimetric methods |
| need of blood transfusion | 24 hours | number of unites of blood transfusion |
| need of uterotonic | 24 hours | misoprostol, oxytocin etc |
| change in hemoglobin | 24 hours | change in hemoglobin |
Outcome results
None listed