Mohs Surgery Combind With Cryotherapy for Eyelid Malignant Tumors.

Mohs Surgery Combind With Cryotherapy for Eyelid Malignant Tumors: a Prospective Randomized Controlled Study.

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05072327

Enrollment

120

Registered

2021-10-08

Start date

2020-10-15

Completion date

2025-12-31

Last updated

2021-10-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eyelid Tumor

Keywords

Eyelid Tumor, Basal Cell Carcinoma, Squamous Cell Carcinoma, Sebaceous Carcinoma, Mohs surgery, cryotherapy

Brief summary

This study aim to investigate whether the prognosis of eyelid malignant tumor is better treated with Mohs surgery combind with cryotherapy than Mohs surgery only.

Detailed description

This study is a randomized perspective study. American Joint Committee on Cancer was applied to define the cancer stage of patients recruited. Patients with Tis to T3cN0M0 will be randomized to receive Mohs surgery or Mohs suregery conbind cryotherapy. Patients will be followed for 3 years.

Interventions

PROCEDUREMohs surgery

Mohs surgery of eyelid

PROCEDUREcryotherapy

cryotherapy of eyelid

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

* Ability to provide written informed consent and comply with study assessments for the full duration of this study. * Definite pathology signs of eyelid basal cell carcinoma, squamous cell carcinoma and sebacous carcinoma, Stage Tis to T3CN0M0 based on American Joint Committee on Cancer. * Pathological examination showed the primary tumor was compeletely resected

Exclusion criteria

* Any previous treatment in the study eye * Tumor complicated with infection * Any other tumors of the paticipants * Intolerate of surgery or anesthesia

Design outcomes

Primary

Measure	Time frame	Description
recurrence rate of tumor	three years	measure the tumor recurrence rate for the two groups at three years
progression rate of tumor	three years	measure the tumor progression rate for the two groups at three years

Secondary

Measure	Time frame	Description
all cause mortailty	three years	measure the mortality rate for the two groups(Cancer-related death and non-Cancer-related death) at three years
side effects of Mohs surgery and cryotherapy in the treatment of eyelid malignant tumor	three years	numbers of participants with side effects

Countries

China

Contacts

Primary ContactHuasheng Yang, M.D, PHD

yanghs64@126.com+862087331539

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026