Bronchiolitis, RSV Infection
Conditions
Keywords
RSV infections in twins, Bronchiolitis, very-severe-LRTI, severe-LRTI, LRTI, upper respiratory tract infection, RSV infection, Human, infant
Brief summary
Respiratory syncytial virus (RSV) infection is the most common cause of severe lower respiratory tract infection (LRTI) in the pediatric population worldwide. Age at the time of infection, prematurity, multiparity, exposure to smoke and the level of passive immunity transmitted at birth are the main risk factors for lower respiratory infection associated with RSV. Other factors, including the innate immune response, respiratory microbiota, and intra-host viral heterogeneity, may also affect outcomes but are not fully considered in RSV infection. Exploring the impact of these factors is difficult due to the heterogeneity of the population which makes statistical adjustment difficult. Thus, twin models are useful in understanding the impact of the host on the environment, as twins often share similar exposure to infection and many risk factors, but not all are ie different prenatal and postnatal conditions, differential transfer of maternal antibodies and the genetic makeup of heterozygotes.
Interventions
OTHEREpidemiology
Assessment of the discrepancy of clinical severity of RSV-infections between twin infants.
Sponsors
Hospices Civils de Lyon
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 354 Days
Healthy volunteers
No
Inclusion criteria
* Twins born at Hospices Civils de Lyon in the years 2012 to 2020 * At least one twin hospitalized with positive RSV-PCR during the first year of life
Exclusion criteria
* Major differential underlying disease between twins * Death of a twin before the RSV epidemic period of the first year of life * Nosocomial infection * Lack of understanding of the study or questionnaire by parents * Lack of parental consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of discordant twin pairs in severity of Respiratory Syncytial Virus infections. | 1 day | The primary outcome measure is the percentage of discordant twin pairs of at least one severity level on the WHO (World Health Organization) scale. The discrepancy in the level of severity is obtained by retrospective analysis of the data from the medical file. |
Countries
France
Outcome results
None listed