Diazepam and Blood Pressure Regulation

The Acute Effects of Diazepam on Blood Pressure Regulation

Status

Completed

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05069779

Enrollment

Registered

2021-10-06

Start date

2017-08-01

Completion date

2019-05-20

Last updated

2021-10-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

Blood pressure, Benzodiazepine, Autonomic nervous system

Brief summary

The aim of this study is to determine the acute effects of diazepam on beat-to-beat blood pressure variability and baroreflex control.

Detailed description

Benzodiazepines are widely prescribed for a variety of clinical conditions. However, its cardiovascular consequences remain controversial. In this study, the investigators sought to determine the acute effects of a single dose of oral diazepam (10mg) on resting beat-to-beat blood pressure variability and cardiac and sympathetic baroreflex sensitivity in a cohort of young, healthy individuals.

Interventions

DRUGDiazepam

Oral administration of 10 mg of diazepam

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* 18 to 40 years of age * Healthy, free of known cardiovascular, metabolic, or musculoskeletal disease

Exclusion criteria

* History of smoking (tobacco or cannabis), defined as any smoking within the past 3 months * Diagnosed cardiovascular or metabolic disease(s) * Prescription of chronic medications other than oral contraceptives * History of hypertension or presence of arrhythmia

Design outcomes

Primary

Measure	Time frame	Description
Resting beat-to-beat blood pressure variability	Change from baseline at 60 min	Finger photoplethysmography
Systolic and diastolic blood pressure	Change from baseline at 60 min	Oscillometric device

Secondary

Measure	Time frame	Description
Muscle sympathetic nerve activity	Change from baseline at 60 min	Microneurography
Baroreflex sensitivity	Change from baseline at 60 min	The relationship between changes in beat-to-beat blood pressure and heart rate (cardiac baroreflex) or MSNA (sympathetic baroreflex).

Countries

Brazil

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026